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Robust, high-performance cell culture clarification
The Stax mAx clarification platform is a single-use, robust, depth filtration solution for the economic clarification of monoclonal antibody cell cultures without the need for centrifugation or process additives.
The filtration stages are optimized to maintain performance as cell density and viability change. This robust performance minimizes the impact of process variability between batches and delivers a platform that works across a wide range of cell cultures.
The platform scales directly with a range of formats and sizes suitable for bench-top testing up to large-scale clinical production. Whatever your process volume, the StaxmAxdepth filtration system assures high throughput and filtrate quality and delivers maximum flexibility, performance, and simplicity in a small footprint to meet all your clarification needs.
用途
What is the Stax mAx platform?
The platform consists of two double-layer HP-series depth filtration grades, PDP8 plus PDE2. These combine to create a 4-layer depth filter system. Stage 1 uses coarse primary clarification filter grades to deliver consistent, high throughputs and Stage 2 adds finer grades to provide high filtrate clarity.
Optimized for cell densities or up to 35 x 106 cells/mL and for culture turbidity of up to 3000 NTU this robust performance makes the Stax
How does the platform perform?
The combination of PDP8 and PDE2 depth filter sheets
This robust, high throughput ensures an economic depth filtration solution can be achieved even with large process volumes. When selected the platform performance is resilient against natural batch-to-batch variations in cell culture characteristics which would traditionally lead to a risk of incomplete harvesting due to premature filter blockage
Scalabilty
The Stax
| Typical Volume |
Format | Filtration Area |
|
| 100 – 300 mL | Supracap™ 50 capsules |
 |
22 cm2 |
| 1 - 10 L | Supracap 100 capsules |
 |
0.025 - 0.1 m2 |
| 25 - 300 L | Stax system capsules |  |
0.25 - 3 m2 |
| 50 - 500 L |  |
0.5 - 5 m2 | |
| 100 - 1000 L |  |
1 - 10 m2 | |
仕様
| Materials of Construction | Supracap 50 Capsules | Supracap 100 Capsules | Stax Capsules |
| Capsule shell | |||
| Manifold assemblies | -- | -- | |
| Internal module | Polypropylene | Polypropylene | Polypropylene |
| Gasket | Silicone | Silicone | Silicone |
| Depth filter media | Cellulose | Cellulose | Cellulose |
For further information regarding extractables data and certifications for the capsules and manifolds please reference the Stax platform validation guide USTR 2528
| Maximum Operating Pressure |
3 bar (44 psi) at 40 °C | 3 bar (44 psi) at 40 °C | 3.5 bar (50 psi) at 25 ºC 1.0 bar (14.3 psi) at 60 ºC |
| Maximum Differential Pressure |
1.5 bar (22 psi) | 1.5 bar (22 psi) | 2.4 bar (35 psi) at 25 ºC |
| Maximum Operating Temperature |
40 °C | 40 °C | 60 °C |
| Sterilization Autoclaving |
1 x 30 minute at 125 °C | 1 x 60 minute at 125 °C | 2 x 60 minute at 125 °C |
| Inlet / Outlet Connections |
Luer | 13 mm (½ in.) hose barb | 25 mm – 38 mm (1 – 1½ in.) sanitary flange |
| Filtration Area | 22 cm2 | 5 in. 0.025 m2 10 in. 0.05 m2 20 in. 0.10 m2 |
Small 0.25 m2 Medium 0.5 m² Large 1.0 m² |
Other configurations available. For further information, contact your local Pall office or distributor
製品カテゴリー
関連資料
Regulatory/Quality Documentation
型式
Supracap 50 Capsules
| Description | Details | Part Number | Surface Area |
| Stage 1 Media grade PDP8 | 6 – 30 µm, PDP8 media (1/pkg) |
SC050PDP8 | 22 cm2 (3.41 in2) |
| Stage 2 Media grade PDE2 | 0.2 - 3.5 µm, PDE2 media (1/pkg) |
SC050PDE2 | 22 cm2 (3.41 in2) |
Supracap 100 Capsules
| Description | Details | Part Number | Surface Area |
| Stage 1 5 in.: Media grade PDP8 | 6 – 30 µm, PDP8 media (1/pkg) |
NP5LPDP87 | 0.025 m2 (0.27 ft2) |
| Stage 2 5 in.: Media grade PDE2 | 0.2 - 3.5 µm, PDE2 media (1/pkg) |
NP5LPDE27 | 0.025 m2 (0.27 ft2) |
| Stage 1 10 in.: Media grade PDP8 | 6 – 30 µm, PDP8 media (1/pkg) |
NP6PDP86 | 0.05 m2 (0.54 ft2) |
| Stage 2 10 in.: Media grade PDE2 | 0.2 - 3.5 µm, PDE2 media (1/pkg) |
NP6PDE26 | 0.05 m2 (0.54 ft2) |
| Stage 1 20 in.: Media grade PDP8 | 6 – 30 µm, PDP8 media (1/pkg) |
NP7PDP86 | 0.10 m2 (1.08 ft2) |
| Stage 2 20 in.: Media grade PDE2 | 0.2 - 3.5 µm, PDE2 media (1/pkg) |
NP7PDE26 | 0.10 m2 (1.08 ft2) |
Part numbers ending in 7: ¼ in (6 mm) hose barb inlet and outlet
Stax Capsules*
| Description | Details | Part Number | Surface Area (m2) |
| Stage 1 Small : Media grade PDP8 | 6 – 30 µm, PDP8 media (1/pkg) |
SXSPDP8402SP | 0.25 m² (2.70 ft²) |
| Stage 2 Small : Media grade PDE2 | 0.2 - 3.5 µm, PDE2 media (1/pkg) |
SXSPDE2402SP | 0.25 m² (2.70 ft²) |
| Stage 1 Medium : Media grade PDP8 | 6 – 30 µm, PDP8 media (1/pkg) |
SXMPDP8404SP | 0.5 m² (5.38 ft²) |
| Stage 2 Medium : Media grade PDE2 | 0.2 - 3.5 µm, PDE2 media (1/pkg) |
SMXPDE2404SP | 0.5 m² (5.38 ft²) |
| Stage 1 Large : Media grade PDP8 | 6 – 30 µm, PDP8 media (1/pkg) |
SXLPDP8408SP | 1.0 m² (10.8 ft²) |
| Stage 2 Large : Media grade PDE2 | 0.2 - 3.5 µm, PDE2 media (1/pkg) |
SXLPDE2408SP | 1.0 m² (10.8 ft²) |
* For Stax manifold and chassis ordering information, please refer to Pall document reference USD2590b
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