Protecting Critical Virus Filtration
Pegasus Protect virus prefiltration combines with Pegasus Prime virus filtration to deliver the first gamma-sterilized pre-filter & virus filter combination. Together, these simplify process development, validation and operations while saving time and delivering improved process economy.
Process developers can quickly deliver a robust, scalable virus filtration process using a minimum of sample volume, and be confident of successful virus validation. This choice supports clinical manufacturing with a solution that is easy to use and versatile to work alone or with integrated and automated single-use systems.
Both gamma irradiated and non-irradiated Microdisc capsules containing Pegasus Protect media are optimized for the confirmation and validation of performance at a small scale using minimal volumes of process fluid.
Performance established during small scale trials can be easily scaled as both Pegasus Protect prefilters and Pegasus Prime virus filters are available in a range of optimized capsule and filter formats which maintain a constant area ratio between prefiltration and virus filtration at all scales.
All process scale devices can be integrated into single-use and automated solutions to offer the highest degree of control, flexibility and security.
Features and Benefits
|Removes filter plugging substances virus filters||Reduce plugging of Pegasus Prime
|The scale-up range provides a consistent prefilter to virus filter area ratio at all scales||Consistent performance
|Fully disposable capsule with Luer connections||Easy-to-use, ready-to-use|
Filter Membrane: Nylon
Housing, Vent Plug and Support: Polypropylene
Pore size : 0.2 μm nominal
Effective Filter Area (EFA) (Nominal)
Maximum Temperature: 40 °C
Maximum Pressure: 3.1bar (45 psi)*
Maximum Differential Pressure: 3.1 bar (45 psi)*
*up to 12 hours at 25 °C; up to 6 hours at 40 °C
Recommended Operating Conditions
35 mbard (0.5 psid) or 2 mL/min water at 20 °C*
*when used with Pegasus Prime Microdisc capsules
Typical Hold-Up Volume (with air purge)
< 125 μL
Length: 2.0 cm (0.8 in.)
Diameter : 3.0 cm (1.2 in.)
Female Luer-Lock inlet, male slip Luer outlet
Impact of Pegasus Protect Prefiltration on Required Virus Flters Per Batch
Prefiltration area and flowrate are critical variables that may affect the performance of Pegasus Protect prefiltration and Pegasus Prime virus removal filters when used in combination.
To control these variables Pegasus Protect prefiltration media is available in a range of formats, designed to maintain a consistent pre-filter to virus-filter ratio. This control ensures predictable and consistent performance at all scales from the initial Microdisc scale trials to clinical manufacturing.
|Area||Microdisc Capsules||Area||Kleenpak / Mini
|Pegasus Protect Prefiltration||3.9 cm2||286 cm2|
|Pegasus Prime Virus Filter||2.8 cm2||204 cm2|
|Area ratio||1.4 : 1||1.4 : 1|
|4MCFPRT4||Pall Microdisc Capsules with Pegasus Protect Filter Membrane||4/box|
|4MCFPRT12||Pall Microdisc Capsules with Pegasus Protect Filter Membrane||12/box
(4 x 3 lots)
|4MCFPRT4R||Pall Microdisc Capsules with Pegasus Protect Filter Membrane - Gamma irradiated||4/box|
|4MCFPRT12R||Pall Microdisc Capsules with Pegasus Protect Filter Membrane - Gamma irradiated||12/box
(4 x 3 lots)