Bioburden Reduction Filters Suitable for High Particulate-Containing Biological Process Streams

Offered in a range of scalable formats, Supor EAV filters deliver high flow rates and effective bioburden reduction and particulate control. These filters are ideal for the following applications:

• Bioburden control filtration of buffers and protein solutions
• Prefiltration of high particulate-containing biological process streams
• Applications where validated sterilizing-grade filters are not essential but reliable bioburden control is required

Superior Performance

Supor EAV filters have a 0.2 µm removal rating and feature a highly asymmetric single-layer polyethersulfone (PES) membrane. These filters can protect and extend the service life of critical sterile filters, mycoplasma control filters, downstream chromatography columns, and ultrafilters when consistent bioburden control is essential, but the use of validated sterilizing-grade filters is not necessary.

• Hydrophilic PES membrane ensures maximum transmission of active ingredients
• Fast and easy scale-up: all process development-scale filter formats are designed to scale directly to larger cGMP filter configurations
• High microbial and particulate reduction with outstanding service life
• Bacterial titer reduction in excess of 6 log guarantees excellent microbial filtration efficiency in processes with variable bioburden
• High-capacity membrane ensures maximum flow and throughput performance for smaller, more cost-effective filtration systems
• Broad pH compatibility due to PES membrane

Security of Supply and Reliability of Performance

Pall manufactures the PES membrane used in Supor EAV filter capsules and cartridges. All Supor EAV pleated filters are made at manufacturing sites in Puerto Rico and the United Kingdom.

Scientifically Validated

With a removal rating of 0.2 µm in liquids, Supor EAV filters are validated for the removal of Brevundimonas diminuta (ATCC 19146) with a typical titer reduction of 10⁶ (6 LRV), assuring safety in applications where an absolute sterility claim is not essential. This rating is supported with comprehensive validation data.