Sterilizing-Grade Filter Membrane With High Chemical (pH) Compatibility and Maximum Transmission of High-Value Active Ingredients

Offered in a range of scalable formats, Supor EKV polyethersulfone (PES) membrane filters are designed for cost-effective filtration of a wide range of liquids including:

• Growth media
• Bioreactor feeds 
• Buffers
• Intermediates

Superior Performance

Supor EKV filters feature 0.2-micron-rated validated sterilizing-grade membranes. With standard 5- and 10-inch format filters utilizing a laid-over-pleat membrane geometry in capsules and cartridges for high flow rates and throughput performance, their PES membrane ensures very high compatibility over the whole pH range and very low protein binding to ensure the maximum transmission of active ingredients.

Benefits

• Very low protein and preservative binding: hydrophilic PES membrane ensures maximum transmission of active ingredients
• Fast and easy scale-up: all process development-scale filter formats are designed to scale directly to larger cGMP filter configurations
• Broad pH compatibility due to PES membrane
• Long life and low filtration costs thanks to a built-in, asymmetric pre-filter layer
• Good wettability for reliable integrity tests

Security of Supply and Reliability of Performance

Pall manufactures the PES membrane used in Supor EKV filter capsules and cartridges. All Supor EKV pleated filters are made at manufacturing sites in Puerto Rico and the United Kingdom.

Scientifically Validated

With an absolute removal rating of 0.2 µm in liquids, the filters are bacterially challenged using Brevundimonas (Pseudomonas) diminuta (ATCC 19146) liquid challenge at 10⁷ cfu/cm², and extensively scientifically validated and supported with a comprehensive validation guide.