mPath™ Benchtop Bioreactor Control Towers product photo Primary L

mPath™ Benchtop Bioreactor Control Towers

Flexible control for single-use cell culture

The mPath controller architecture provides powerful process control for the unique needs of single-use bioprocessing. Emphasizing robustness, ease-of-use and flexibility, mPath controllers combine the robustness of manufacturing with the flexibility of process development. The architecture, based on programmable logic controllers (PLCs) outperforms microcontroller based embedded systems typically seen at this scale. When integrated with Pall bioreactors, mPath control towers easily handle process development (PD), seed applications and small scale manufacturing. Flexible options for single-use sensors, variable speed pumps, networking and interfaces allow customization to individual process needs. Six precision mass flow controllers and three biocontainer hangers with integrated load cells track process inputs accurately. With advanced features designed for single-use, mPath controllers put fewer limits on your processes and your creativity.

Features and Benefits

 
Features Benefits
Control Software – Pall Link
The mPath control tower is designed for operation
with Pall Link – a supervisory control and data acquisition (SCADA) software package
  • Capable of accessing data anywhere on any networked device including laboratory workstations, desktop computers or remote devices such as laptops, mobile phones and tablets
  • Operates as either a standalone network or integrated with site IT systems, compatible with multiple network security approaches (e.g. virtual private network [VPN]) and password protection to protect bioreactors from unauthorized access
  • Intuitive visual displays for easy interaction with bioreactors to calibrate components, set critical parameters, and fine tune process control
  • Advanced trending capability including creation of custom trends of any process variable for both historic and live processes
  • Database centric design supports naming, logging and exporting experiments for traceability and data analysis
  • Full alarm customization to alert for process or safety critical events
  • Management features for user-definable recipes including scheduling, version control and retirement for recipes no longer in use
  • Compliance capability – designed for operation following 21 CFR Part 11/Annex 11 regulations
Advanced Alarming
Multiple notification modalities to
ensure response to process critical events
        Control Tower
  • Color coded illumination ring around the front face of the controller allows identification of operating state from a distance
  • Individual LED indicators for each connection on the connector panel identify problems during set up and operation
        Pall Link
  • Highly visible color and textual alerts which indicate alarm severity on all software interfaces
  • Historical alarm logs to review equipment and process performance
Gas Handling
More flexibility in gas control – six oxygen-rated thermal mass flow
controllers (TMFCs) pre-calibrated
for process gases
  • Accurate gas mixing for two gas streams enabling accurate parameter control and complex gas control regimes, each gas within the mix delivered by a dedicated TMFC
    – Primary gas mix: N2, O2, Air and CO2
    – Secondary gas mix: CO2 and Air
  • Calibrated flow rates up to 1 L/min for each TMFC
  • Onboard regulators ensure accuracy of TMFC even with higher input pressures
  • Onboard pressure sensors, combined with alarming capability enable notification of empty gas cylinders or biocontainer overpressure
  • Fast fill button – quick and safe inflation of biocontainers with air
Optional Liquid Handling
More accuracy in liquid delivery – three variable speed pumps,
integrated load cells and
biocontainer hangers
  • Accurate delivery of feeds and titrants without compromises, standard variable speed pumps enable smoother process control and feed profiles for less process variability
    – 8 mm max tubing outside diameter (OD)
    – 14 - 211 rpm (control requiring speeds less than 14 rpm achieved through pulse width modulation [PWM])
  • Removable pump heads for easy cleaning and serviceability
  • Removable biocontainer hangers with integrated load cells allow space efficient execution of weight based feed profiles and accurate tracking of titrant delivery
Ergonomics and Space
Designed with people in mind to simplify the use and maintenance of bioreactor controllers
  • Extensive human factors research to determine optimal placement of connections and control tower elements
  • Flexibility in operation – choose when and where to view data, choose how to design processes
  • Compact design to limit bench space requirements – small form factor and biocontainer hangers remove the need for scales and bottles
  • Elevated from bench for cleanability
 


Download Datasheet
Description

Flexible control for single-use cell culture

The mPath controller architecture provides powerful process control for the unique needs of single-use bioprocessing. Emphasizing robustness, ease-of-use and flexibility, mPath controllers combine the robustness of manufacturing with the flexibility of process development. The architecture, based on programmable logic controllers (PLCs) outperforms microcontroller based embedded systems typically seen at this scale. When integrated with Pall bioreactors, mPath control towers easily handle process development (PD), seed applications and small scale manufacturing. Flexible options for single-use sensors, variable speed pumps, networking and interfaces allow customization to individual process needs. Six precision mass flow controllers and three biocontainer hangers with integrated load cells track process inputs accurately. With advanced features designed for single-use, mPath controllers put fewer limits on your processes and your creativity.

Features and Benefits

 
Features Benefits
Control Software – Pall Link
The mPath control tower is designed for operation
with Pall Link – a supervisory control and data acquisition (SCADA) software package
  • Capable of accessing data anywhere on any networked device including laboratory workstations, desktop computers or remote devices such as laptops, mobile phones and tablets
  • Operates as either a standalone network or integrated with site IT systems, compatible with multiple network security approaches (e.g. virtual private network [VPN]) and password protection to protect bioreactors from unauthorized access
  • Intuitive visual displays for easy interaction with bioreactors to calibrate components, set critical parameters, and fine tune process control
  • Advanced trending capability including creation of custom trends of any process variable for both historic and live processes
  • Database centric design supports naming, logging and exporting experiments for traceability and data analysis
  • Full alarm customization to alert for process or safety critical events
  • Management features for user-definable recipes including scheduling, version control and retirement for recipes no longer in use
  • Compliance capability – designed for operation following 21 CFR Part 11/Annex 11 regulations
Advanced Alarming
Multiple notification modalities to
ensure response to process critical events
        Control Tower
  • Color coded illumination ring around the front face of the controller allows identification of operating state from a distance
  • Individual LED indicators for each connection on the connector panel identify problems during set up and operation
        Pall Link
  • Highly visible color and textual alerts which indicate alarm severity on all software interfaces
  • Historical alarm logs to review equipment and process performance
Gas Handling
More flexibility in gas control – six oxygen-rated thermal mass flow
controllers (TMFCs) pre-calibrated
for process gases
  • Accurate gas mixing for two gas streams enabling accurate parameter control and complex gas control regimes, each gas within the mix delivered by a dedicated TMFC
    – Primary gas mix: N2, O2, Air and CO2
    – Secondary gas mix: CO2 and Air
  • Calibrated flow rates up to 1 L/min for each TMFC
  • Onboard regulators ensure accuracy of TMFC even with higher input pressures
  • Onboard pressure sensors, combined with alarming capability enable notification of empty gas cylinders or biocontainer overpressure
  • Fast fill button – quick and safe inflation of biocontainers with air
Optional Liquid Handling
More accuracy in liquid delivery – three variable speed pumps,
integrated load cells and
biocontainer hangers
  • Accurate delivery of feeds and titrants without compromises, standard variable speed pumps enable smoother process control and feed profiles for less process variability
    – 8 mm max tubing outside diameter (OD)
    – 14 - 211 rpm (control requiring speeds less than 14 rpm achieved through pulse width modulation [PWM])
  • Removable pump heads for easy cleaning and serviceability
  • Removable biocontainer hangers with integrated load cells allow space efficient execution of weight based feed profiles and accurate tracking of titrant delivery
Ergonomics and Space
Designed with people in mind to simplify the use and maintenance of bioreactor controllers
  • Extensive human factors research to determine optimal placement of connections and control tower elements
  • Flexibility in operation – choose when and where to view data, choose how to design processes
  • Compact design to limit bench space requirements – small form factor and biocontainer hangers remove the need for scales and bottles
  • Elevated from bench for cleanability
 
Specifications
 
Item mPath Bioreactor Control Tower
Weight Weight <20 kg
Dimensions H=450 mm, L=600 mm, W=230 mm
Gas Requirements Air, nitrogen, oxygen and carbon dioxide
Minimum supply pressure 2.5 bar (36.3 psi)
Maximum supply pressure 6.0 bar (87.0 psi)
EMC Directive 2014/30/EU BS EN 61326-1: 2013
Low Voltage Directive (LVD) 2014/35/EU BS EN 61010-1: 2010
Machinery Directive 2006/42/EC BS EN ISO 12100: 2010
RoHS Directive All components RoHS compliant (2011/65/EU)
IP Rating Designed and tested - IP 54 (IP54 IEC 60529)
Electrical Data Voltage Universal input: 100 – 240 V AC
Input frequency: 50/60 Hz
Power Consumption 360 W maximum
Electrical Power Cables USA, UK and European
Operating System Pall Link Link server: Microsoft Windows 10 Pro
Control tower: Microsoft Windows Embedded Compact
Oracle: MySQL and Java
Operating Conditions Laboratory environment
Temperature range +5 °C (+41 °F) to +40 °C (+104 °F)
Up to 90% relative humidity
Non-condensing
Storage Conditions Temperature range -20 °C (-4 °F) to +50 °C (+122 °F)
Up to 90% relative humidity
Non-condensing
 
Ordering Information

The mPath control towers are available for use with Pall benchtop bioreactors, including:

  • Allegro™ XRS 25 rocking bioreactor
  • Xpansion® multiplate bioreactor system
  • iCELLis® Nano bioreactor system
  • PadReactor® Mini bioreactor system

Please contact your sales representative at bioreactors@pall.com or www.pall.com

Segment
Cell Culture