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iCELLis® Single-Use Fixed-Bed Bioreactor Systems

Productivity and Reduced Footprint for Industrialization of Animal Cell Culture Processes in a Fixed-Bed Bioreactor

The iCELLis bioreactor system is an automated, single-use, fixed-bed bioreactor that provides excellent cell growth conditions for adherent cells.

  • Cell culture process simplification, from vial to product
  • Fully-integrated, single-use iCELLis 500+ bioreactor with disposable, pre-installed calibrated probes
  • Unique waterfall system for optimal oxygenation and CO2 stripping
  • Compact high-cell-density, fixed-bed bioreactor providing a significant increase in volumetric productivity vs. traditional stirred tanks
  • Predictable scalability from R&D to manufacturing
  • Significant decrease in operational costs and capital investments vs. classical 2D flatware
Full information about this product is available from the product datasheet.
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Description

Productivity and Reduced Footprint for Industrialization of Animal Cell Culture Processes in a Fixed-Bed Bioreactor

The iCELLis bioreactor system is an automated, single-use, fixed-bed bioreactor that provides excellent cell growth conditions for adherent cells.

  • Cell culture process simplification, from vial to product
  • Fully-integrated, single-use iCELLis 500+ bioreactor with disposable, pre-installed calibrated probes
  • Unique waterfall system for optimal oxygenation and CO2 stripping
  • Compact high-cell-density, fixed-bed bioreactor providing a significant increase in volumetric productivity vs. traditional stirred tanks
  • Predictable scalability from R&D to manufacturing
  • Significant decrease in operational costs and capital investments vs. classical 2D flatware
Full information about this product is available from the product datasheet.

Applications

The iCELLis bioreactor systems are available in two formats:

  • The iCELLis Nano system for feasibility studies and small-scale production (up to 4 m2)
  • The iCELLis 500+ system for industrial scale manufacturing (up to 500 m2)
 

iCELLis Nano system

iCELLis 500+ system

Performance

The fixed-bed design of the iCELLis system makes it the perfect solution for industrialization of adherent cell processes and virus production for both gene therapy and vaccines, providing a large cell growth surface area while keeping the footprint very small. The iCELLis system accommodates up to 500 m2 of growth area, which, when compared with available surfaces of multitray systems and roller bottles, corresponds to a huge reduction in volumes. The iCELLis 500+/500 m2 system is equivalent to 794 cell stacks with 10 trays and 5,882 roller bottles at 850 cm2 each. In addition to volume reduction, the use of a filled, fixed-bed in the iCELLis system enables higher specific productivity than in other culture systems.

Type

Bioreactors

Use

Cell Culture

Product Summary

iCELLis® Bioreactor by Pall is the world's first fully integrated high-cell density bioreactor designed to simplify processes by combining advantages of both single-use technologies and a fixed bed system. The system is ideal from pre-culture to final production causing a dramatic decrease in operational costs. Bioreactor has linear scalability features to match any system from R&D to manufacturing.

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