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mPath™ Benchtop Bioreactor Control Towers

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mPath™ Benchtop Bioreactor Control Towers

Flexible Control for Single-Use Cell Culture

The mPath controller architecture provides powerful process control for the unique needs of single-use bioprocessing. Emphasizing robustness, ease-of-use and flexibility, mPath bioreactor controllers combine the robustness of manufacturing with the flexibility of process development. The architecture, based on programmable logic controllers (PLCs) outperforms microcontroller based embedded systems typically seen at this scale. When integrated with Pall bioreactors, mPath control towers easily handle process development (PD), seed applications and small-scale manufacturing. Flexible options for single-use sensors, variable speed pumps, networking and interfaces allow customization to individual process needs. Six precision mass flow controllers and three biocontainer bag hangers with integrated load cells track process inputs accurately. With advanced features designed for single-use, mPath controllers put fewer limits on your processes and your creativity.

Features and Benefits


Features	Benefits
Control Software – mPath Link The mPath control tower is designed for operation with mPath Link server – a supervisory control and data acquisition (SCADA) software package	Capable of accessing data anywhere on any networked device including laboratory workstations, desktop computers or remote devices such as laptops, mobile phones and tablets Operates as either a standalone network or integrated with site IT systems, compatible with multiple network security approaches (e.g. virtual private network [VPN]) and password protection to protect bioreactors from unauthorized access Intuitive visual displays for easy interaction with bioreactors to calibrate components, set critical parameters, and fine tune process control Advanced trending capability including creation of custom trends of any process variable for both historic and live processes. Overlay and compare trends from multiple batches on one graph Database centric design supports naming, logging and exporting batches for traceability and data analysis Full alarm customization to alert for process or safety critical events User-definable recipes including scheduling, version control and retirement for recipes no longer in use. Recipes can be multi-phased with user-defined transitions between each phase Compliance capability – designed for operation following 21 CFR Part 11/Annex 11 regulations
Advanced Alarming Multiple notification modalities to ensure response to process critical events	Control Tower Color coded illumination ring around the front face of the controller allows identification of operating state from a distance Individual LED indicators for each connection on the connector panel identify problems during set up and operation mPath Link Software Highly visible color and textual alerts which indicate alarm severity on all software interfaces Historical alarm logs to review equipment and process performance
Gas Handling More flexibility in gas control – six oxygen-rated thermal mass flow controllers (TMFCs) pre-calibrated for process gases	Accurate gas mixing for two gas streams enabling accurate parameter control and complex gas control regimes, each gas within the mix delivered by a dedicated TMFC – Primary gas mix: N₂, O₂, Air and CO₂ – Secondary gas mix: CO₂ and Air Calibrated flow rates up to 1 L/min for each TMFC Onboard regulators ensure accuracy of TMFC even with higher input pressures Onboard pressure sensors, combined with alarming capability enable notification of empty gas cylinders or biocontainer overpressure Fast fill button – quick and safe inflation of biocontainers with air
Optional Liquid Handling More accuracy in liquid delivery – three variable speed pumps, integrated load cells and biocontainer bag hangers	Accurate delivery of feeds and titrants without compromises, standard variable speed pumps enable smoother process control and feed profiles for less process variability – 8 mm max tubing outside diameter (OD) – 14 - 211 rpm (control requiring speeds less than 14 rpm achieved through pulse width modulation [PWM]) Removable pump heads for easy cleaning and serviceability Removable biocontainer bag hangers with integrated load cells allow space efficient execution of weight based feed profiles and accurate tracking of titrant delivery
Ergonomics and Space Designed with people in mind to simplify the use and maintenance of bioreactor controllers	Extensive human factors research to determine optimal placement of connections and control tower elements Flexibility in operation – choose when and where to view data, choose how to design processes Compact design to limit bench space requirements – small form factor and biocontainer bag hangers remove the need for scales and bottles Elevated from bench for cleanability

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Description

Flexible Control for Single-Use Cell Culture

Features and Benefits


Features	Benefits
Control Software – mPath Link The mPath control tower is designed for operation with mPath Link server – a supervisory control and data acquisition (SCADA) software package	Capable of accessing data anywhere on any networked device including laboratory workstations, desktop computers or remote devices such as laptops, mobile phones and tablets Operates as either a standalone network or integrated with site IT systems, compatible with multiple network security approaches (e.g. virtual private network [VPN]) and password protection to protect bioreactors from unauthorized access Intuitive visual displays for easy interaction with bioreactors to calibrate components, set critical parameters, and fine tune process control Advanced trending capability including creation of custom trends of any process variable for both historic and live processes. Overlay and compare trends from multiple batches on one graph Database centric design supports naming, logging and exporting batches for traceability and data analysis Full alarm customization to alert for process or safety critical events User-definable recipes including scheduling, version control and retirement for recipes no longer in use. Recipes can be multi-phased with user-defined transitions between each phase Compliance capability – designed for operation following 21 CFR Part 11/Annex 11 regulations
Advanced Alarming Multiple notification modalities to ensure response to process critical events	Control Tower Color coded illumination ring around the front face of the controller allows identification of operating state from a distance Individual LED indicators for each connection on the connector panel identify problems during set up and operation mPath Link Software Highly visible color and textual alerts which indicate alarm severity on all software interfaces Historical alarm logs to review equipment and process performance
Gas Handling More flexibility in gas control – six oxygen-rated thermal mass flow controllers (TMFCs) pre-calibrated for process gases	Accurate gas mixing for two gas streams enabling accurate parameter control and complex gas control regimes, each gas within the mix delivered by a dedicated TMFC – Primary gas mix: N₂, O₂, Air and CO₂ – Secondary gas mix: CO₂ and Air Calibrated flow rates up to 1 L/min for each TMFC Onboard regulators ensure accuracy of TMFC even with higher input pressures Onboard pressure sensors, combined with alarming capability enable notification of empty gas cylinders or biocontainer overpressure Fast fill button – quick and safe inflation of biocontainers with air
Optional Liquid Handling More accuracy in liquid delivery – three variable speed pumps, integrated load cells and biocontainer bag hangers	Accurate delivery of feeds and titrants without compromises, standard variable speed pumps enable smoother process control and feed profiles for less process variability – 8 mm max tubing outside diameter (OD) – 14 - 211 rpm (control requiring speeds less than 14 rpm achieved through pulse width modulation [PWM]) Removable pump heads for easy cleaning and serviceability Removable biocontainer bag hangers with integrated load cells allow space efficient execution of weight based feed profiles and accurate tracking of titrant delivery
Ergonomics and Space Designed with people in mind to simplify the use and maintenance of bioreactor controllers	Extensive human factors research to determine optimal placement of connections and control tower elements Flexibility in operation – choose when and where to view data, choose how to design processes Compact design to limit bench space requirements – small form factor and biocontainer bag hangers remove the need for scales and bottles Elevated from bench for cleanability

Specifications


Item	mPath Control Tower
Weight	< 20 kg
Dimensions	230 mm (W) x 600 mm (D) x 450 mm (H) (H = 590 mm with hangers installed)
Gas Requirements	Air, nitrogen, oxygen and carbon dioxide Minimum supply pressure 2.5 bar (36.3 psi) Maximum supply pressure 6.0 bar (87.0 psi)
EMC Directive 2014/30/EU	BS EN 61326-1: 2013
Low Voltage Directive (LVD) 2014/35/EU	BS EN 61010-1: 2010
Machinery Directive 2006/42/EC	BS EN ISO 12100: 2010
RoHS (Restriction of Hazardous Substances) Directive	All components RoHS compliant (2011/65/EU)
IP (Ingress Protection) Rating	Designed and tested - IP 54 (IP54 IEC 60529)
Electrical Data	Voltage universal input: 100 – 240 V AC Input frequency: 50/60 Hz
Power Consumption	360 W maximum
Electrical Power Cables	USA, UK and European
Operating System	Microsoftu Windows♦ Embedded Compact
Operating Conditions	Laboratory environment Temperature range +5 °C (+41 °F) to +40 °C (+104 °F) Up to 90% relative humidity Non-condensing
Storage Conditions	Temperature range -20 °C (-4 °F) to +50 °C (+122 °F) Up to 90% relative humidity Non-condensing


Item	mPath Link Server PC
Memory (RAM)	16 GB
Central Processing Unit (CPU)	1 x Intel♦ i3-8100 3.60 GHz
Storage	1 TB
Software/Operating System	Ignition♦, Windows 10 LTSC, MySQL♦ Standard

Software Details


Software License	Specification
Windows 10 LTSC	Win 10 IoT Ent 2019 LTSC MultiLang ESD OEI Value
Windows MSSQL	Microsoft SQL Server♦ IoT 2019 Standard 4 Core (ESD)
Ignition v8.1	Ignition Perspective License (unlimited) Ignition OPC UA Server Module Ignition Tag Historian License Java embedded

Hardware Details


Component Name	Component information
Motherboard	BCM MX310HD (rev.1.0)
Memory (RAM) 16 GB	Crucial♦ CT8G4SFS8266 M8FD
CPU	Intel i3-8100 3.60 GHz
CPU (FAN)	DYNATRON K199 (i3-i7)
Storage Media	Samsung♦ 860 QV0
PSU	XP ALM85US19C2-8
Ports	5 x USB 2 x Ethernet HDMI