Resolute® Columns product photo Primary L

Resolute® Columns

Resolute columns are ideally suited for process purification in the biopharmaceutical industry. A patented nozzle valve provides all column functions required for packing, unpacking and running of the column in a closed system. Based on established and well proven designs, the Resolute column provides improved column performance and true linear scalability combined with reproducible column packing methods for today’s high performance media.

Pall continues to work closely with the biopharmaceutical manufacturing industry to advance the state of the art for both chromatographic performance and productivity. The packing process is controlled by a slurry packing system which,

combined with a Resolute column, offers a complete solution for process chromatography from development to manufacturing scale. 

Features and Benefits

  • Standard column diameters from 280 mm to 1200 mm – all with selectable bed heights from  100 mm up to 600 mm  
  • Bed Height: fixed or adjustable (200 mm adjustment)
  • Nozzle Valve: choice of manually operated Resolute DM, or pneumatically actuated Resolute DP columns
  • Choice of bed supports in polyethylene or stainless steel
  • Piston seal and precision bore tube eliminates need for additional mechanical compression or pneumatic activation of adjuster seals
  • Compatible with a wide range of Chromatographic Media
 

Sanitary Design

Resolute Chromatography Column

 
  • Fully flushed flow path and adjuster seal for clean-in-place (CIP)
  • Minimum dead space fixed cell seal arrangement
  • Reduced risk of corrosion
    • non metallic nozzle flow path for high  salt and low pH conditions
    • forged stainless steel tube eliminates weld seams on tube wall and flanges
  • Visible valve flow path aids detection of entrapped air
  • Sanitary clamp terminations
  • Leachate free acrylic tube — no phthalates
  • Peroxide cured seals — no sulphur containing leachate
  • Process wetted materials meet regulatory requirements

Column Options

Standard Columns

  • Actuated nozzle valve; fits 400 to 1200 mm diameter columns
  • Bed supports:
    • Polyethylene 10/20/60 µm
    • Stainless steel 10/20/50 µm
  • Lockable castors and adjustable feet supplied as standard*
  • Up to 1000 mm diameter only.

Engineered Columns

  • Operating pressure up to 7 bar
  • Columns from 400 mm to 2000 mm diameter
  • Certification to ASME Div VIII sec 1 or PD5500.CE where applicable
  • End-cell Rotation Frames (ERF)
  • Alternative materials: Hastalloy C22, Stainless Steel 1.4435, 1.4439
  • Hydraulic Actuators — see technical specifications for operating modes

View additional chromatography columns.

Products in this datasheet may be covered by one or more patents including :
EP 1 085 931
US 6,446,679



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Description

Resolute columns are ideally suited for process purification in the biopharmaceutical industry. A patented nozzle valve provides all column functions required for packing, unpacking and running of the column in a closed system. Based on established and well proven designs, the Resolute column provides improved column performance and true linear scalability combined with reproducible column packing methods for today’s high performance media.

Pall continues to work closely with the biopharmaceutical manufacturing industry to advance the state of the art for both chromatographic performance and productivity. The packing process is controlled by a slurry packing system which,

combined with a Resolute column, offers a complete solution for process chromatography from development to manufacturing scale. 

Features and Benefits

  • Standard column diameters from 280 mm to 1200 mm – all with selectable bed heights from  100 mm up to 600 mm  
  • Bed Height: fixed or adjustable (200 mm adjustment)
  • Nozzle Valve: choice of manually operated Resolute DM, or pneumatically actuated Resolute DP columns
  • Choice of bed supports in polyethylene or stainless steel
  • Piston seal and precision bore tube eliminates need for additional mechanical compression or pneumatic activation of adjuster seals
  • Compatible with a wide range of Chromatographic Media
 

Sanitary Design

Resolute Chromatography Column

 
  • Fully flushed flow path and adjuster seal for clean-in-place (CIP)
  • Minimum dead space fixed cell seal arrangement
  • Reduced risk of corrosion
    • non metallic nozzle flow path for high  salt and low pH conditions
    • forged stainless steel tube eliminates weld seams on tube wall and flanges
  • Visible valve flow path aids detection of entrapped air
  • Sanitary clamp terminations
  • Leachate free acrylic tube — no phthalates
  • Peroxide cured seals — no sulphur containing leachate
  • Process wetted materials meet regulatory requirements

Column Options

Standard Columns

  • Actuated nozzle valve; fits 400 to 1200 mm diameter columns
  • Bed supports:
    • Polyethylene 10/20/60 µm
    • Stainless steel 10/20/50 µm
  • Lockable castors and adjustable feet supplied as standard*
  • Up to 1000 mm diameter only.

Engineered Columns

  • Operating pressure up to 7 bar
  • Columns from 400 mm to 2000 mm diameter
  • Certification to ASME Div VIII sec 1 or PD5500.CE where applicable
  • End-cell Rotation Frames (ERF)
  • Alternative materials: Hastalloy C22, Stainless Steel 1.4435, 1.4439
  • Hydraulic Actuators — see technical specifications for operating modes

View additional chromatography columns.

Products in this datasheet may be covered by one or more patents including :
EP 1 085 931
US 6,446,679

Specifications

Material Specifications

 
Process Wetted Components
Column Tube Acrylic (cast PMMA) or Stainless Steel 316L (1.4404)
Distribution Cell Polypropylene
Nozzle Body PVDF/Acrylic(1)
Process Terminations and Slurry Nozzle Tip PEEK
Slurry Inlet Port 180 and 280 mm columns: (2) PEEK
400 to 1200 mm columns: (2) Stainless Steel 316L
Bed Support Polyethylene sinter or Stainless Steel mesh
Seals EPDM (Peroxide cured)
FEP encapsulated silicone
Wiper Blade PTFE
 

 
External Components
Stand, Adjustable Feet Stainless Steel 316L
Castor Stainless Steel 304L
Castor Tyre Polyurethane
 
(1) PVDF/PVDF version available for increased chemical resistance.
(2) Components not in mobile phase flow path.


Column Specifications

 
Resolute Fixed and Adjustable Columns
180 – 1200 mm (7 – 47 in.) diameter
Operating Pressure 180 – 280 mm (7 – 11 in.): 
5 bar (73) psi
400 – 1200 mm (15.7 – 47 in.):
3 bar (44) psi
Operating Temperature 2 – 30 ºC (35 – 86 °F)
Bed Support, Type and Rating Stainless Steel Mesh:
10, 20, 50 µm
Polyethylene Sinter:
10, 20, 60 µm
Product Flow Path Stainless Steel surface finish
< 0.6 µm Ra, Electropolished
Exterior Components Stainless Steel surface finish
< 0.9 µm Ra, Electropolished
Pressure Retaining Plates Stainless Steel surface finish
< 1.5 µm Ra, 240 (UK) Grit Sateen
Column Frame Stainless Steel surface finish
Bright polished
Media Transfer Nozzle DM:
Manual actuation
DP:
Manual control with pneumatic actuation
 

Hydraulic Actuators (Optional)

 
Type Mode of Operation Application
HEP
Hydraulic Endcell Positioning
Hydraulic linear actuator when column is empty or primed and has an open flow path with < 1 bar column pressure Set up prior to Pack in Place and Maintenance
DAP
Dynamic Axial Packing
Hydraulic linear actuator when column is empty or filled with slurry and has an open flow path with < 3.0 bar column pressure Flow Packing at optimal linear velocity
/M Option
Hoist-free Maintenance
Actuators and integral support and safety devices move and secure Top Adjuster and Column Tube (/M option available for either HEP or DAP model) Access to top and bottom bed supports and seals for changeout
 
Ordering Information
This is a list of typical part numbers for this product range. For part numbers and configurations that are that are not listed, please contact your Pall representative.

Column Capacity and Ordering Information

 
Description Diameter CSA Adjustable Height Adjustable Capacity Operating Pressure
Resolute 280 280 mm (11.in.) 620 cm2 100 – 300 mm  6.2 – 18.5 L 5 bar (73 psi)
Resolute 400 400 mm (15.7 in.) 1260 cm2 100 – 300 mm 12.6 – 37.7 L 3 bar (44 psi)
Resolute 600 600 mm (23.6 in.) 2830 cm2 100 – 300 mm  28.3 – 84.8 L 3 bar (44 psi) 

Resolute 800

800 mm (2.6 ft) 5030 cm2 100 – 300 mm  50.3 – 150 L 3 bar (44 psi)
Resolute 1000 1000 mm (3.2 ft) 7850 cm2 100 – 300 mm  79 – 235 L 3 bar (44 psi)
Resolute 1200 1200 mm (3.9 ft) 11310 cm2 100 – 300 mm  113 – 339 L 3 bar (44 psi)
Resolute 1400 1400 mm (4.6 ft) 15390 cm2  100 – 300 mm 154 – 461 L 3 bar (44 psi)
Resolute 1600 1600 mm (5.2 ft) 20110 cm2 100 – 300 mm 201 – 603 L 3 bar (44 psi)
Resolute 1800 1800 mm (5.9 ft) 25450 cm2 100 – 300 mm 255 – 763 L 3 bar (44 psi)
Resolute 2000 2000 mm (6.6 ft) 31420 cm2 100 – 300 mm 314 – 942 L 3 bar (44 psi)
 

 

Application
Columns - Standard
Segment
Chromatography