mPath™ IoR Concentration Monitor product photo Primary L

mPath™ IoR Concentration Monitor

Monitor Protein Concentration in Real Time With Pall’s Inline Index of Refractivity (IoR) System

Pall’s mPath IoR concentration monitor provides accurate inline continuous measurement of product concentration in bioprocess fluids, enabling more rapid development and characterization of biotech processes. These measurements enable scientists to quickly see the impact of process changes on product yield, allowing fast determination of optimal process parameters.

Better Insight Into Your Process

Concentration measurements can give valuable insight into the performance of cells, the efficiency of clarification and purification steps, and the state of ultrafiltration operations. Continuous inline data collection enables better control and characterization of unit operations, reducing the chance of undetected process deviations and saving time.

More Data Means More Process Knowledge

Faster measurement of protein concentration enables faster characterization of processes, which empowers scientists with the ability to generate more knowledge and spend less time waiting for assays to deliver results.

 
Features and Benefits
Online sensors
  • Data collected in real time (sample rate of 1 second), enabling responses to
    concentration without waiting for results from assays
  • No sampling required, enabling closed system monitoring
Index of refractivity (IoR) measurement
  • Superior accuracy and response time
  • Wider linear range than ultra violet (UV)
  • Suitable for all typical bioprocess unit operations
  • Measures accurately even in non-conductive fluids
Up to 4 sensors per monitor
  • Collect concentration data at multiple critical points in a process simultaneously
3 m (10 ft) flow cell cable length
  • Monitor all sensors from a single location in the room
No consumable or spare parts
  • Virtually no hardware maintenance
Simple Windows application software
  • Start up, calibrate, and collect data within minutes
Compact sensors and monitor
  • Use less laboratory space and easily transport the monitor
PTFE* sensors
 
* Polytetrafluoroethylene    ** Sensor must be sterilized by flush-through prior to use

Organize a Trial

Contact your local Pall representative to request a trial with the mPath IoR concentration monitor. Pall’s Scientific and Laboratory Services (SLS) can visit your site and demonstrate the ease of use of the mPath IoR concentration monitor, as well as help to generate some trial data ready for evaluation.

mPath IoR concentration monitor flow cell


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mPath™ IoR Concentration Monitor Kit with 1⁄16” flow cell product photo

mPath™ IoR Concentration Monitor Kit with 1⁄16” flow cell

Product ID: MPATHRI1-KIT16-1
Unit of Measure
1/EA
Min Order Qty
1
mPath™ IoR Concentration Monitor Kit with ¼" flow cell product photo

mPath IoR Conc Monit Kit 1/4" x1

Product ID: MPATHRI1-KIT04-1
Unit of Measure
1/EA
Min Order Qty
1
Description

Monitor Protein Concentration in Real Time With Pall’s Inline Index of Refractivity (IoR) System

Pall’s mPath IoR concentration monitor provides accurate inline continuous measurement of product concentration in bioprocess fluids, enabling more rapid development and characterization of biotech processes. These measurements enable scientists to quickly see the impact of process changes on product yield, allowing fast determination of optimal process parameters.

Better Insight Into Your Process

Concentration measurements can give valuable insight into the performance of cells, the efficiency of clarification and purification steps, and the state of ultrafiltration operations. Continuous inline data collection enables better control and characterization of unit operations, reducing the chance of undetected process deviations and saving time.

More Data Means More Process Knowledge

Faster measurement of protein concentration enables faster characterization of processes, which empowers scientists with the ability to generate more knowledge and spend less time waiting for assays to deliver results.

 
Features and Benefits
Online sensors
  • Data collected in real time (sample rate of 1 second), enabling responses to
    concentration without waiting for results from assays
  • No sampling required, enabling closed system monitoring
Index of refractivity (IoR) measurement
  • Superior accuracy and response time
  • Wider linear range than ultra violet (UV)
  • Suitable for all typical bioprocess unit operations
  • Measures accurately even in non-conductive fluids
Up to 4 sensors per monitor
  • Collect concentration data at multiple critical points in a process simultaneously
3 m (10 ft) flow cell cable length
  • Monitor all sensors from a single location in the room
No consumable or spare parts
  • Virtually no hardware maintenance
Simple Windows application software
  • Start up, calibrate, and collect data within minutes
Compact sensors and monitor
  • Use less laboratory space and easily transport the monitor
PTFE* sensors
 
* Polytetrafluoroethylene    ** Sensor must be sterilized by flush-through prior to use

Organize a Trial

Contact your local Pall representative to request a trial with the mPath IoR concentration monitor. Pall’s Scientific and Laboratory Services (SLS) can visit your site and demonstrate the ease of use of the mPath IoR concentration monitor, as well as help to generate some trial data ready for evaluation.

mPath IoR concentration monitor flow cell
Applications
  • Column switching in a continuous chromatography process
  • Constant concentration monitoring in a tangential flow filtration (TFF) process, enabling you to stop when the desired concentration is reached
  • Evaluating the protein retention of depth filtration
  • Buffer preparation using IoR as a concentration indicator
  • Measuring concentration in upstream anddownstream processing
Specifications

Product Specifications 

Flow cell materials of construction
  • Flow cell body : PTFE
  • Optical window : Sapphire glass
  • Cable (non-wetted) : Polypropylene (PP)
  • Bonnet (non-wetted) : PP
Flow cell dimensions 90 x 90 x 20 mm
Flow cell mass 0.1 kg
Flow cell connections 3/4 in. Tri-Clamp connections
Monitor dimensions 183 x 193 x 34 mm
Monitor mass 0.5 kg
Monitor electrical requirements 24 V (DC), 0.5 A minimum
Power supply requirements (included) 110 / 240 V (AC), 50 / 60 Hz
Screen 26 x 77 mm LCD screen
Signal cable RS-232 (monitor end)
IP67 12-pole, 1 A panel mount connector (flow cell end)
Analog output 4 – 20 mA for temperature and IoR
Number of flow cells per monitor Up to 4
Software Windows-based interface for setup, monitoring, data logging,
and calibration.

Downloadable from https://www.pall.com/en/biotech/mpath-ior.html

System requirements for software Windows 98 or higher, 128 MB RAM
 
Performance

Operating and Performance Information 

Monitor ambient temperature operating range 20 – 30 °C
Flow cell temperature range 5 – 50 °C
Flow cell pressure range 0 – 5.5 barg (0 – 80 psig)
IoR range 1.28000 – 1.40000
Protein linear concentration range (monoclonal antibody) 0.003 – 320 g/L*
IoR accuracy 2 x 10-4
IoR repeatability 2.5 x 10-5
IoR resolution) 1 x 10-5
Response time 1.2 seconds standard (rolling average configurable)
 
* Theoretical linear range. Pall data confirms 0.1 – 250 g/L
Type
Concentration Monitors
Use
Concentration Monitoring
Ordering Information

Ordering Information

 
Part Number Description
MPATHRI1-KIT16-1 Kit containing the display unit and 1 flow cell – 1/16 in. bore
MPATHRI1-KIT04-1 Kit containing the display unit and 1 flow cell – ¼ in. bore
MPATHRI1-FC16 1 flow cell, 1/16 in. bore*
MPATHRI1-FC04 1 flow cell, ¼ in. bore*
MPATHRI1-FCCBL Flow cell connection cable
MPATHRI1-SIGCBL Signal cable (for spares only)
MPATHRI1-PWRCBL Power cable (for spares only)
MPATHRI1-DDU1 Display unit and power cable, no flow cells (for spares only)
 
* Does not include flow cell connection cable. If ordering as a supplemental flow cell, MPATHRI1-FCCBL will be required. If ordering as a replacement flow cell, a new flow cell connection cable is not necessary.