Supradisc™ HP Depth Filter Modules product photo Primary L

Supradisc™ HP Depth Filter Modules

For High Performance Cell Clarification

Pall Supradisc HP modules include two full thickness, graded, high efficiency, depth filter layers in combination. This technology enhances process clarification steps such as whole cell and cell lysate separations. Difficult to filter processes such as centrifuge supernatants and culture media can also benefit from Pall’s Supradisc HP technology. HP depth filter media is comprised of two distinct layers of Seitz® P-series depth filter sheets, a more permeable layer followed by a less permeable layer. These performance-enhanced depth filters have been designed for low viability and applications containing high solids. With many new processes containing higher debris loads and with the wider distribution of particle sizes in biotech applications, conventional depth filter technology may no longer achieve desired performance. Pall Supradisc HP depth filters provide the robustness and performance for current process demands.

Features and Benefits

  • Designed to provide maximum throughput for biological, bioprocess and pharmaceutical filtration
  • High purity pharmaceutical grade depth filter media, optimized for low endotoxins and low extractables levels
  • High dirt holding capacity combined with very low protein adsorption and long service life
  • Excellent removal of a wide range of suspended particles down to sub-micron size in a wide range of cell culture applications. Supradisc HP modules ensure high protection for subsequent sterile filters as well as chromatography columns
  • Compress clarification processing steps to save time and resources and to reduce operating costs
  • All components meet the specifications for the biological test listed in the current version of the USP Class VI 121 °C 
  • Supradisc HP modules and all their components are fully traceable
  • Available in Supracap™ 100 and 200 encapsulated formats for applications that require disposable formats 
  • Validation guide available upon request

Selection of Pall Supradisc HP Media

 
Media Type Description Application
 PDK5  Highest dirt holding capacity  Post Fermentation
 PDH4  High dirt holding capacity and good membrane protection  Post Fermentation
 PDE2  Excellent membrane protection  Post Centrifuge
 PDD1  Tightest media combination, outstanding membrane protection  Post Centrifuge/Post TFF
 

High Quality and FDA Conformity

The filter sheets meet the specifications set forth in the US Code of Federal Regulations Title 21, parts 177.2260 e,f,g,h,i,j,k,l. The materials for all plastic components are listed in US Code of Federal Regulations Title 21, part 177.1520.

With regard to food law conformity, the manufacture of depth filter sheets is also subject to ongoing analysis by the German ISEGA Forschungsund Untersuchungsgesellschaft mbH, Aschaffenburg.

Technical Service

For best possible results and maximum reliability, Pall recommends performing filter evaluations utilizing your process and process conditions. Pall specialists can provide valuable assistance, either at your facility or in our SLS (Scientific and Laboratory Services) laboratories. Pall offers hands-on assistance and places its extensive technical resources at your disposal in the form of worldwide technical advice, including cost-reduction programs, process review and problem solving.

Further Information

Further information is available on Pall's range of Filter Modules and Capsules with Seitz Depth Filter Media



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Description

For High Performance Cell Clarification

Pall Supradisc HP modules include two full thickness, graded, high efficiency, depth filter layers in combination. This technology enhances process clarification steps such as whole cell and cell lysate separations. Difficult to filter processes such as centrifuge supernatants and culture media can also benefit from Pall’s Supradisc HP technology. HP depth filter media is comprised of two distinct layers of Seitz® P-series depth filter sheets, a more permeable layer followed by a less permeable layer. These performance-enhanced depth filters have been designed for low viability and applications containing high solids. With many new processes containing higher debris loads and with the wider distribution of particle sizes in biotech applications, conventional depth filter technology may no longer achieve desired performance. Pall Supradisc HP depth filters provide the robustness and performance for current process demands.

Features and Benefits

  • Designed to provide maximum throughput for biological, bioprocess and pharmaceutical filtration
  • High purity pharmaceutical grade depth filter media, optimized for low endotoxins and low extractables levels
  • High dirt holding capacity combined with very low protein adsorption and long service life
  • Excellent removal of a wide range of suspended particles down to sub-micron size in a wide range of cell culture applications. Supradisc HP modules ensure high protection for subsequent sterile filters as well as chromatography columns
  • Compress clarification processing steps to save time and resources and to reduce operating costs
  • All components meet the specifications for the biological test listed in the current version of the USP Class VI 121 °C 
  • Supradisc HP modules and all their components are fully traceable
  • Available in Supracap™ 100 and 200 encapsulated formats for applications that require disposable formats 
  • Validation guide available upon request

Selection of Pall Supradisc HP Media

 
Media Type Description Application
 PDK5  Highest dirt holding capacity  Post Fermentation
 PDH4  High dirt holding capacity and good membrane protection  Post Fermentation
 PDE2  Excellent membrane protection  Post Centrifuge
 PDD1  Tightest media combination, outstanding membrane protection  Post Centrifuge/Post TFF
 

High Quality and FDA Conformity

The filter sheets meet the specifications set forth in the US Code of Federal Regulations Title 21, parts 177.2260 e,f,g,h,i,j,k,l. The materials for all plastic components are listed in US Code of Federal Regulations Title 21, part 177.1520.

With regard to food law conformity, the manufacture of depth filter sheets is also subject to ongoing analysis by the German ISEGA Forschungsund Untersuchungsgesellschaft mbH, Aschaffenburg.

Technical Service

For best possible results and maximum reliability, Pall recommends performing filter evaluations utilizing your process and process conditions. Pall specialists can provide valuable assistance, either at your facility or in our SLS (Scientific and Laboratory Services) laboratories. Pall offers hands-on assistance and places its extensive technical resources at your disposal in the form of worldwide technical advice, including cost-reduction programs, process review and problem solving.

Further Information

Further information is available on Pall's range of Filter Modules and Capsules with Seitz Depth Filter Media

Specifications

Media Technical Specification

 
Code Depth Filter Type Typical Water
Permeability
in L/min/m2
@ Δp 1 bar
(14.5 psid)
Nominal Retention Rating in µm Ash Content in % Endotoxin Level
in EU/mL
before Rinsing
 PDD1 PDD1   25  0.1-0.85  52  <0.06
 PDE2  PDE2  35  0.2-3.5  47 <0.06 
 PDH4  PDH4  93  0.5-15.0  45  <0.06
 PDK5 PDK5  151   1.5-20.0  45 <0.06
 

Permeability 1

1 Test performed with water at 20 °C and a differential pressure of 1 bard (14.5 psid)

Micron Range

Typical Values for Ions after Rinsing with 100 L/m2 WFI

 
Ca Mg Fe Cu Al Ni
< 0.5 ppm  < 0.1 ppm   < 0.1 ppm < 0.1 ppm  < 0.05 ppm  < 0.01 ppm 
 

Operating Characteristics *

 
Maximum Operating Temperature 80 °C 
 Maximum Differential Pressure  2.4 bard (35 psid)
 

* With compatible fluids, which do not soften, swell or adversely affect the products or its material of construction

Plastic Parts of Construction

 
Molded Parts Polypropylene
O-rings Platinum-cured Silicone Elastomer 
 

Sterilization

 
 Steam in place  125 °C for 30 minutes at 0.3 bard (4.3 psid) maximum
 

Nominal Dimensions

 
 Diameter 284 mm (12 in.) in 210 configuration
410 mm (16 in.) in 410 and 440 configuration
 Filter Area 1.0 m2 (11 ft2) in 210 configuration
2.5 m2 (27.0 ft2) in 410 and 440 configuration

 Total Length:
 Double O-ring Style
 Flat Gasket Style 

 
332 mm (13 in.)
272 mm (11 in.)
 
For regulatory and validation information please refer to the contact Pall for the validation guide documents for Pall P-series Depth Filter Media and Pall SUPRAdisc HP Depth Filter Media.
Furthermore the following documents are available on request:
  • Technical Data Sheet
  • Certificate of Analysis 
  • EU Safety Data Sheet

Important Note:- Use of this product in a manner other than in accordance with Pall’s current recommendations may lead to injury or loss. Pall cannot accept liability for such
injury or loss. Because of developments in technology, these data and/or procedures are subject to continual review and update. Please contact Pall for additional  information.

Application
Filters - Depth
Segment
Depth Filtration