Centramate™ 500 S Tangential Flow Filtration System product photo Primary L

Centramate™ 500 S Tangential Flow Filtration System

Scalable Production Technology
in a Compact Benchtop System

The Centramate™ 500 S benchtop tangential flow filtration system provides biotechnology and biopharmaceutical drug developers & manufacturers with an ultra-compact portable unit for process development in ultrafiltration (UF) and microfiltration (MF) applications.

Designed for all applications requiring concentration and diafiltration of suspended microparticulates (such as cell suspensions and lysates) or dissolved solutes (such as proteins or nucleic acids), the sanitary, self-venting, fully drainable design meets the demands of cGMP environments, with full traceability of process-wetted materials. Using the Centramate 500 S system for process development, time, risk and process volumes are all minimized.

Features

  • Compact Flowpath - the ultra-compact flow path of the Centramate 500 S system allows users to operate at volumes as low as 170mL (when using a single Centramate membrane cassette) enabling high concentration factors and minimizing operating volumes
  • Scalable Process Technology - designed through experience, the Centramate 500 S system meets the requirements for cGMP equipment with a comprehensive qualification and documentation package, calibrated process instrumentation and hygienic design
  • Direct Flow Measurement - the magnetic inductive flowmeter provides direct flow measurement during operation, making system operation safe, accurate and user- friendly
  • High Yield and Product Recovery - the hygienic, completely drainable flow path of the Centramate 500 S system enables high product yield, optimum product recovery and easy cleaning
  • Safety in Operation - an adjustable pressure interlock provides product and operator safety in a robust and reliable TFF system
  • Pressure Independent Flow - the four-piston diaphragm pump delivers constant flow even as the system pressure increases
  • Data Logging Capability - data from the process instrumentation can be exported to a PC or laptop computer via the USB port on the Centramate 500 S system
  • Documentation Package
    • Calibration certificates for measuring instruments
    • Drawings (P&ID, Layout)
    • User manual
    • Electrical wiring documentation incl. certificates
    • Welding documentation incl. certificates
    • Supplier literature
    • 3.1 certificates for product wetted parts
    • FDA conformity (EPDM); CE declaration
    • Generic IQ documentation

Benefits

  • The graduated glass vessel provides full visibility and indication of fluid level during operation, so volumes can be closely controlled
  • The positive displacement diaphragm pump provides pressure independent flow, ensuring critical parameters do not vary during concentration
  • Scalable process technology makes the system ideal for scale-up and scale-down studies
  • Direct flow measurement with the magnetic inductive flowmeter means accurate, safe and simple operation
  • With an interlock controlling the recirculation pump, operator and product safety is maximized
  • To eliminate transcription and recording errors, the Centramate 500 S system has a built in data acquisition system which can be connected to a PC via a USB cable
  • The data can be displayed on the screen and exported to the hard drive of a connected computer. The data can be imported easily into Microsoft* Excel*
*Microsoft and Excel are trademarks of Microsoft

Click here to download a brochure for the Centramate 500 S TFF System (PDF, 2.7 Mb)



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Description

Scalable Production Technology
in a Compact Benchtop System

The Centramate™ 500 S benchtop tangential flow filtration system provides biotechnology and biopharmaceutical drug developers & manufacturers with an ultra-compact portable unit for process development in ultrafiltration (UF) and microfiltration (MF) applications.

Designed for all applications requiring concentration and diafiltration of suspended microparticulates (such as cell suspensions and lysates) or dissolved solutes (such as proteins or nucleic acids), the sanitary, self-venting, fully drainable design meets the demands of cGMP environments, with full traceability of process-wetted materials. Using the Centramate 500 S system for process development, time, risk and process volumes are all minimized.

Features

  • Compact Flowpath - the ultra-compact flow path of the Centramate 500 S system allows users to operate at volumes as low as 170mL (when using a single Centramate membrane cassette) enabling high concentration factors and minimizing operating volumes
  • Scalable Process Technology - designed through experience, the Centramate 500 S system meets the requirements for cGMP equipment with a comprehensive qualification and documentation package, calibrated process instrumentation and hygienic design
  • Direct Flow Measurement - the magnetic inductive flowmeter provides direct flow measurement during operation, making system operation safe, accurate and user- friendly
  • High Yield and Product Recovery - the hygienic, completely drainable flow path of the Centramate 500 S system enables high product yield, optimum product recovery and easy cleaning
  • Safety in Operation - an adjustable pressure interlock provides product and operator safety in a robust and reliable TFF system
  • Pressure Independent Flow - the four-piston diaphragm pump delivers constant flow even as the system pressure increases
  • Data Logging Capability - data from the process instrumentation can be exported to a PC or laptop computer via the USB port on the Centramate 500 S system
  • Documentation Package
    • Calibration certificates for measuring instruments
    • Drawings (P&ID, Layout)
    • User manual
    • Electrical wiring documentation incl. certificates
    • Welding documentation incl. certificates
    • Supplier literature
    • 3.1 certificates for product wetted parts
    • FDA conformity (EPDM); CE declaration
    • Generic IQ documentation

Benefits

  • The graduated glass vessel provides full visibility and indication of fluid level during operation, so volumes can be closely controlled
  • The positive displacement diaphragm pump provides pressure independent flow, ensuring critical parameters do not vary during concentration
  • Scalable process technology makes the system ideal for scale-up and scale-down studies
  • Direct flow measurement with the magnetic inductive flowmeter means accurate, safe and simple operation
  • With an interlock controlling the recirculation pump, operator and product safety is maximized
  • To eliminate transcription and recording errors, the Centramate 500 S system has a built in data acquisition system which can be connected to a PC via a USB cable
  • The data can be displayed on the screen and exported to the hard drive of a connected computer. The data can be imported easily into Microsoft* Excel*
*Microsoft and Excel are trademarks of Microsoft

Click here to download a brochure for the Centramate 500 S TFF System (PDF, 2.7 Mb)

Specifications

Operating Conditions

Pressure Range  0 to 6 barg (0 to 87 psig)
Temperature Range 0° C to +45° C (32° F to 113° F)
Flow Rate 15 - 600 L/hr

Operating Volumes

Maximum Working Volume¹ 5 liter (nominal)
Minimum Working Volume² 170 mL
¹ 5 liter is the maximum batch volume. Larger volumes can be processed using a fed-batch approach
² 170 mL is the minimum working volume when using a single Centramate membrane cassette. Actual minimum working volume will be dependent on the installed membrane area and should be measured

Dimensions and Weight

Dimensions W 480 mm x L 605 mm x H 945 mm (W 19" x L 24" x H 37")
Weight 50 kg (110 lb)

Power Requirements

CM500SE Version  220 V / 50 Hz
CM500SW Version 110V / 60 Hz
Power 370 W

Component Specifications

COMPONENT TYPE MATERIALS SURFACE FINISH CAPACITY/OTHER
Cassette Holder Centramate 316L Stainless Steel 0.8 μm Ra, electropolished  0.1 - 0.5 m² membrane area 
Tie-rods & Washers N/A 304 Stainless Steel N/A N/A
Nuts N/A Bronze  N/A  N/A
Vessel N/A  Borosilicate Glass  N/A  5 L 

Recirculation Pump

4 piston diaphragm pump 316L Stainless Steel 0.8μm Ra, electropolished 600 L/hr
Diaphragm N/A Santoprene* N/A N/A
Flowmeter Magnetic Inductive 316L Stainless Steel 0.8μm Ra, electropolished 600 L/hr
Pressure Indicator N/A N/A N/A  N/A 
Chemical Seal N/A  316L Stainless Steel  0.8μm Ra  -1 to +6 bar 
Transmitter 2-wire system  N/A N/A 4 - 20 mA
Valves Diaphragm 316L Stainless Steel 0.8μm Ra, electropolished N/A
Diaphragm N/A EPDM N/A N/A
Piping Weldron, longitudinal seamed 316L Stainless Steel 0.8μm Ra, electropolished N/A 
Gaskets ½ inch sanitary EPDM N/A  N/A 
Vessel Outlet / Inlet Tubing N/A Silicon  N/A N/A 
Frame Enclosed square profile 304 Stainless Steel N/A N/A
Cabinet N/A 304 Stainless Steel N/A IP54
* Santoprene is a trademark of Advanced Elastomer Systems

Ordering Information

Systems Information

Description Part Number
Centramate 500 S TFF System - 220 V / 50 Hz CM500SE
Centramate 500 S TFF System – 110 V / 60 Hz CM500SW

Spare Parts

Vessel
O-ring CM005OR
Vessel lid  CM005LD
Vessel lid clamp CM005LC
Support & clamp (including rubber) CM005GS
Vessel inlet /outlet tubing CM005TU
Glass Vessel CM005GR
Components  
Pressure Sensor CM012PS
Flow Sensor CM012FS
Drain Valve CM012DV
System Valve CM012SV
Pump - membrane and spare kit PQ808X01

Application
Systems - Classic