T-Series TFF Cassettes with Omega PES Membrane product photo Primary L

T-Series TFF Cassettes with Omega PES Membrane

High Performance Omega PES Membrane Combined with Significant Material and Design Improvements Deliver Highly Reliable Fluid Dynamics and Better Process Economics


  • Easy implementation into your process. The new T-series cassettes offer significant improvements in construction and design while utilizing the same proven Omega polyethersulfone (PES) membrane to reduce revalidation requirements.
  • Increased safety, reliability, and reproducibility. Superior new materials of construction are durable and stable, exhibit very low extractables, and offer broad chemical compatibility.
  • High flux, high selectivity, and low protein binding are achieved through the use of Omega PES membrane.
  • Improved process performance. Cassettes are designed to provide optimal mass transfer to improve your process economics. 
  • Easy scale up for robust purification processes. Available in scalable formats with the same materials of construction from development to production-scale processes.   
  • Enhanced validation. T-series cassettes surpass the latest biopharmaceutical and regulatory standards such as biological reactivity, extractables, and TOC. Product claims are backed by extensive validation documentation to support the use of T-Series cassettes in your process.

Proven Omega Membrane

Pall's Omega polyethersulfone (PES) membranes offer high flux and selectivities. They have been specifically modified to minimize protein binding to the surface and interstitial structure of the membrane. This polymeric membrane is stable against biological and physical degradation due to the unique chemical properties of PES. 

Omega membranes are cast on a highly porous, non-woven polyolefin support. They have an anisotropic structure, a thin skin-like top layer with a highly porous underlying support. The structure of the skin determines the porosity and permeability characteristics of the membrane and can typically be cleaned quicker and easier than membranes with a uniform, sub-micron depth structure. This membrane is compatible with acids, bases and a variety of other cleaning agents. Omega membranes are available in a wide range of nominal molecular weight cutoffs (NMWC).

The T-Series Advantage

Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:
  • The feed and permeate screen material for T-Series cassettes is made from polypropylene which is highly resistant to sodium hydroxide.
  • Larger feed and permeate ports provide lower pressure drops.
  • T-Series cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.


* Required
Need Help?
Download Datasheet
Description

High Performance Omega PES Membrane Combined with Significant Material and Design Improvements Deliver Highly Reliable Fluid Dynamics and Better Process Economics


  • Easy implementation into your process. The new T-series cassettes offer significant improvements in construction and design while utilizing the same proven Omega polyethersulfone (PES) membrane to reduce revalidation requirements.
  • Increased safety, reliability, and reproducibility. Superior new materials of construction are durable and stable, exhibit very low extractables, and offer broad chemical compatibility.
  • High flux, high selectivity, and low protein binding are achieved through the use of Omega PES membrane.
  • Improved process performance. Cassettes are designed to provide optimal mass transfer to improve your process economics. 
  • Easy scale up for robust purification processes. Available in scalable formats with the same materials of construction from development to production-scale processes.   
  • Enhanced validation. T-series cassettes surpass the latest biopharmaceutical and regulatory standards such as biological reactivity, extractables, and TOC. Product claims are backed by extensive validation documentation to support the use of T-Series cassettes in your process.

Proven Omega Membrane

Pall's Omega polyethersulfone (PES) membranes offer high flux and selectivities. They have been specifically modified to minimize protein binding to the surface and interstitial structure of the membrane. This polymeric membrane is stable against biological and physical degradation due to the unique chemical properties of PES. 

Omega membranes are cast on a highly porous, non-woven polyolefin support. They have an anisotropic structure, a thin skin-like top layer with a highly porous underlying support. The structure of the skin determines the porosity and permeability characteristics of the membrane and can typically be cleaned quicker and easier than membranes with a uniform, sub-micron depth structure. This membrane is compatible with acids, bases and a variety of other cleaning agents. Omega membranes are available in a wide range of nominal molecular weight cutoffs (NMWC).

The T-Series Advantage

Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:
  • The feed and permeate screen material for T-Series cassettes is made from polypropylene which is highly resistant to sodium hydroxide.
  • Larger feed and permeate ports provide lower pressure drops.
  • T-Series cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.
Applications
T-Series cassettes with Omega membrane are designed for development, pilot, and production-scale TFF applications in diverse biological and biopharmaceutical processes. They are especially useful in:
  • Vaccine and conjugate concentration and diafiltration    
  • Purification and recovery of monoclonal antibodies (mAb) or recombinant proteins
  • Blood plasma fractionation and purification

Product Platforms

T-Series cassettes complement Pall’s highly successful Centramate™ and Centrasette™ products, and have been developed following years of experience designing and optimizing our customers’ biotech and biopharmaceutical processes.

T-Series cassettes for Centramate holders are offered in scalable membrane formats with effective filtration areas (EFA) from as low as 200 cm2 (0.215 ft2) to 0.5 m2 (5.4 ft2), making them ideal for process development and small-scale production of 0.1 L to 125 L. Centrasette T-Series cassettes, in combination with Centrasette holders, can process thousands of liters with installations incorporating hundreds of square meters of EFA.
Specifications

Materials of Construction

 
Membrane Omega polyethersulfone
Support Polyolefin
Screens Polypropylene
Encapsulent Polyurethane with white pigment (TiO2)
Permeate Seals Platinum cured silicone
Gaskets Medical grade, platinum cured silicone
 

Operating Limits

 
Maximum Pressure1 6 barg (90 psig) @ 23 °C
4 barg (60 psig) @ 55 °C
Maximum TMP 4 barg (60 psig) @ 55 °C
Temperature Range2 -5 – 55 °C
pH Range 2 – 14
 
1Pressure rating will be dependant on rating of the lowest system component.
2Cassettes must not be allowed to freeze.

Typical Operating Parameters

 
Cross Flow Rate for Processing 5 – 7 L/min/m2 (0.5 – 0.7 L/min/ft2)
Cross Flow Rate for Cleaning 8 – 10 L/min/m2 (0.8 – 1.0 L/min/ft2)
 

Integrity Test

 
Test Pressure 2 barg (30 psig)
Maximum Air Forward Flow < 1600 sccm/m2 (< 150 sccm/ft2)
 

Shelf Life

The shelf life of cassettes packaged in 0.3 N sodium hydroxide is expected to be three years from the date of manufacture when the cassettes are stored unopened in the original packaging at 4 – 25 °C and protected from direct light. Extended shelf life studies are ongoing. 

Biological Safety

All of the materials of construction in the T-Series cassettes have been tested and meet requirements for United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>
at 70 °C.
Performance

Figure 1

Omega 10 kD Membrane, Centramate C vs. T-Series Membrane Cassettes at a 5 L/min/m2Cross Flow Rate 

Ordering Information
Ordering Information

This is a guide to the part number structure and availability of T-Series cassettes. For example, the part number OS 010 T12 is an Omega membrane, 10 kDa NMWC, 0.1 m2 (1.1 ft2) Centramate screen channel cassette.

 
[OS]
Code

Membrane

Description
OS Omega Low protein binding, modified polyethersulfone
 
 
[xxx]
Code
NMWC
001 1 kDa
003 3 kDa
005 5 kDa
010 10 kDa
030 30 kDa
050 50 kDa
070 70 kDa
100 100 kDa
300 300 kDa
 
 
[Txx]
Code
Type and Area Screen Channel
T01 Centramate 0.01 m2 (0.1 ft2)
T02 Centramate 0.02 m2 (0.2 ft2)
T12 Centramate 0.1 m2 (1.1 ft2)
T06 Centrasette 0.5 m2 (5.4 ft2)
T26 Centrasette 2.5 m2 (27 ft2)
 


Read More Read Less
Application
Cassettes
Segment
Tangential Flow Filtration