Cadence® Single-Use Tangential Flow Filtration (TFF) Modules product photo Primary L

Cadence® Single-Use Tangential Flow Filtration (TFF) Modules

A simpler, easier and safer single-use TFF solution for R&D, clinical or commercial manufacturing

Pall’s single-use tangential flow filtration (SUTFF) modules are ready-to-use gamma-irradiated cassette modules that can be integrated into single-use TFF set-ups. They provide ease-of-use, quick turnaround and increased flexibility and safety in cGMP operations.
Pall’s Cadence single-use TFF modules can be easily implemented in single-use TFF systems for concentration and diafiltration steps from R&D to commercial production of biotech products or vaccines.
Integrating the process-proven Omega™ polyethersulfone (PES) membrane, Cadence single-use TFF modules are available in scalable formats from 93 cm² up to 2.5 m² of membrane area.

Key Attributes

  • Simpler and easier solutions: preassembled, ready-to-use modules for easy integration into single-use TFF systems.
  • Safer solutions: single-use, gamma irradiated modules for product and operator safety.
 
Feature Benefit
  • Cadence single-use TFF modules are delivered as preassembled modules that have been gamma irradiated at ≥ 25 kGy
  • Ease of installation and integration in single-use TFF systems
  • Supplied preconditioned, stored in water and gamma irradiated. the modules do not require comprehensive conditioning steps prior to use (see figure 1). Typically less than 20 L/m² flush volumes are required to reach total organic carbon (TOC) levels below 1 ppm.
  • Improved productivity, reducing downtime and allowing focus on product processing operations only
  • No chemical handling
  • Reduction of buffer or water for injection (WFI) consumption
  • Cadence single-use TFF modules integrate the process-proven Omega PES membrane and are scalable.
  • Scalable formats, streamlining product development and process optimization
  • Tests have shown that the process performances of Cadence single-use TFF modules are comparable to reusable Omega T-series cassettes, thus offering the flexibility to switch from single-use to reuse TFF options and vice-versa with limited validation work.
  • Improved process robustness
  • Reliable and flexible process solutions
 

Figure 1

Comparison of TFF operations, reusable cassettes versus single-use with Pall’s Cadence modules


* Normalized water permeability

Product Platform

Cadence single-use TFF modules are available in five formats with the following membrane areas:

  • 93 cm²
  • 186 cm²
  • 0.1 m²
  • 2.5 m²
  • 0.5 m²

They integrate process-proven Pall Omega polyether sulfone (PES) membranes to offer high flux and selectivities. The Omega membranes have been specifically modified to minimize protein binding.
Cadence single-use TFF modules are available with Omega membrane in three different nominal molecular weight cutoffs (NMWC) – 10, 30 and 100 kDa – meeting the majority of the needs for single-use TFF applications in the biotech and vaccines industries.
They can be installed and torqued into Pall’s specially designed holders and with single-use set-ups (Figure 3 and 4). See specifications of Pall’s holders for Cadence SUTFF modules

Figure 2

Cadence single-use TFF modules with 186 cm², 0.1 m² and 0.5 m² membrane area (from left to right)



Figure 3

Installation of the Cadence single-use TFF module into its holder (vertically)



Figure 4

Pall’s Cadence SUTFF module installed horizontally in its holder


Quality Standards

  • Manufactured in a controlled environment
  • Manufactured under a quality management system certified to ISO 9001 standards
  • Supplied with a Certificate of Quality confirming the quality standards and quality control tests performed by Pall
  • The fluid path meets all regulatory requirements for:
    • Biological Reactivity Tests (in vivo) for Class VI-70°C Plastics, USP <88>
    • Biological Reactivity Tests (in vitro) for Cytotoxicity, USP <87>


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Single-Use TFF Module, Omega PES membrane, 100 kDa molecular weight cut-off (MWCO), 0.02 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 100 kDa molecular weight cut-off (MWCO), 0.02 m² effective filtration area (EFA)

Product ID: CSUM100T002
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 30 kDa molecular weight cut-off (MWCO), 0.1 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 30 kDa molecular weight cut-off (MWCO), 0.1 m² effective filtration area (EFA)

Product ID: CSUM030T010
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 10 kDa molecular weight cut-off (MWCO), 0.01 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 10 kDa molecular weight cut-off (MWCO), 0.01 m² effective filtration area (EFA)

Product ID: CSUM010T001
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 10 kDa molecular weight cut-off (MWCO), 0.02 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 10 kDa molecular weight cut-off (MWCO), 0.02 m² effective filtration area (EFA)

Product ID: CSUM010T002
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 30 kDa molecular weight cut-off (MWCO), 0.02 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 30 kDa molecular weight cut-off (MWCO), 0.02 m² effective filtration area (EFA)

Product ID: CSUM030T002
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 100 kDa molecular weight cut-off (MWCO), 0.1 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 100 kDa molecular weight cut-off (MWCO), 0.1 m² effective filtration area (EFA)

Product ID: CSUM100T010
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 100 kDa molecular weight cut-off (MWCO), 0.01 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 100 kDa molecular weight cut-off (MWCO), 0.01 m² effective filtration area (EFA)

Product ID: CSUM100T001
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 10 kDa molecular weight cut-off (MWCO), 0.1 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 10 kDa molecular weight cut-off (MWCO), 0.1 m² effective filtration area (EFA)

Product ID: CSUM010T010
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes
Single-Use TFF Module, Omega PES membrane, 30 kDa molecular weight cut-off (MWCO), 0.01 m² effective filtration area (EFA) product photo

Single-Use TFF Module, Omega PES membrane, 30 kDa molecular weight cut-off (MWCO), 0.01 m² effective filtration area (EFA)

Product ID: CSUM030T001
Unit of Measure
1/EA
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
See All Attributes

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Datasheets

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Description

A simpler, easier and safer single-use TFF solution for R&D, clinical or commercial manufacturing

Pall’s single-use tangential flow filtration (SUTFF) modules are ready-to-use gamma-irradiated cassette modules that can be integrated into single-use TFF set-ups. They provide ease-of-use, quick turnaround and increased flexibility and safety in cGMP operations.
Pall’s Cadence single-use TFF modules can be easily implemented in single-use TFF systems for concentration and diafiltration steps from R&D to commercial production of biotech products or vaccines.
Integrating the process-proven Omega™ polyethersulfone (PES) membrane, Cadence single-use TFF modules are available in scalable formats from 93 cm² up to 2.5 m² of membrane area.

Key Attributes

  • Simpler and easier solutions: preassembled, ready-to-use modules for easy integration into single-use TFF systems.
  • Safer solutions: single-use, gamma irradiated modules for product and operator safety.
 
Feature Benefit
  • Cadence single-use TFF modules are delivered as preassembled modules that have been gamma irradiated at ≥ 25 kGy
  • Ease of installation and integration in single-use TFF systems
  • Supplied preconditioned, stored in water and gamma irradiated. the modules do not require comprehensive conditioning steps prior to use (see figure 1). Typically less than 20 L/m² flush volumes are required to reach total organic carbon (TOC) levels below 1 ppm.
  • Improved productivity, reducing downtime and allowing focus on product processing operations only
  • No chemical handling
  • Reduction of buffer or water for injection (WFI) consumption
  • Cadence single-use TFF modules integrate the process-proven Omega PES membrane and are scalable.
  • Scalable formats, streamlining product development and process optimization
  • Tests have shown that the process performances of Cadence single-use TFF modules are comparable to reusable Omega T-series cassettes, thus offering the flexibility to switch from single-use to reuse TFF options and vice-versa with limited validation work.
  • Improved process robustness
  • Reliable and flexible process solutions
 

Figure 1

Comparison of TFF operations, reusable cassettes versus single-use with Pall’s Cadence modules


* Normalized water permeability

Product Platform

Cadence single-use TFF modules are available in five formats with the following membrane areas:

  • 93 cm²
  • 186 cm²
  • 0.1 m²
  • 2.5 m²
  • 0.5 m²

They integrate process-proven Pall Omega polyether sulfone (PES) membranes to offer high flux and selectivities. The Omega membranes have been specifically modified to minimize protein binding.
Cadence single-use TFF modules are available with Omega membrane in three different nominal molecular weight cutoffs (NMWC) – 10, 30 and 100 kDa – meeting the majority of the needs for single-use TFF applications in the biotech and vaccines industries.
They can be installed and torqued into Pall’s specially designed holders and with single-use set-ups (Figure 3 and 4). See specifications of Pall’s holders for Cadence SUTFF modules

Figure 2

Cadence single-use TFF modules with 186 cm², 0.1 m² and 0.5 m² membrane area (from left to right)



Figure 3

Installation of the Cadence single-use TFF module into its holder (vertically)



Figure 4

Pall’s Cadence SUTFF module installed horizontally in its holder


Quality Standards

  • Manufactured in a controlled environment
  • Manufactured under a quality management system certified to ISO 9001 standards
  • Supplied with a Certificate of Quality confirming the quality standards and quality control tests performed by Pall
  • The fluid path meets all regulatory requirements for:
    • Biological Reactivity Tests (in vivo) for Class VI-70°C Plastics, USP <88>
    • Biological Reactivity Tests (in vitro) for Cytotoxicity, USP <87>

Specifications

Technical Specifications

Pall's TFF modules are single-use and supplied after receiving a gamma irradiation dose of ≥ 25 kGy.

 
Module component Material of construction
Membrane Polyethersulfone
Support Polyolefin
Screens Polypropylene
Encapsulant Polyurethane with white pigment (TiO2)
Seals Platinum cured silicone and thermoplastic elastomer
Manifold plates Glass bead reinforced polypropylene with white pigment (TiO2)/td>
Port caps Polypropylene for luer lock connections, polyethylene for sanitary fittings
Covers High impact polystyrene
 

Operating Parameters

 
Recommended maximum operating feed pressure 4 barg (58 psig)
Maximum transmembrane pressure (TMP) 4 barg (58 psig)
Temperature range during processing 4-40 °C
Temperature range during pre-use sanitization 18-25 °C
Recommended cross flow rate 5 – 7 L/min/m² (0.5 – 0.7 L/min/ft²)
Typical operating time 8 hours
 

Pall's single-use TFF modules must be used in an appropriate holder. They are integrated in single-use TFF systems. The operating limits of the system should also be considered.



Nominal Dimensions

 
Part number (1)   CSUMxxxT001 CSUMxxxT002 CSUMxxxT010 CSUMxxxT050 CSUMxxxT250
Reference drawing   Drawing 1 Drawing 1 Drawing 2 Drawing 3 Drawing 3
Nominal dimensions   mm (in) mm (in) mm (in) mm (in) mm (in)
Length A 212 (8.4) 212 (8.4) 212 (8.4) 218 (8.6) 218 (8.6)
Overall length B 212 (8.4) 212 (8.4) 212 (8.4) 232 (9.2) 232 (9.2)
Thickness (for reference only) C 44 (1.7) 44 (1.7) 55 (2.2) 74 (2.9) 130 (5.1)
Overall thickness (for reference only) D 44 (1.7) 44 (1.7) 60 (2.4) 86 (3.4) 142 (5.6)
Width E 62 (2.4) 62 (2.4) 62 (2.4) 186 (7.3) 186 (7.3)
Overall width F 76 (3.0) 76 (3.0) 112 (4.4) 245 (9.6) 245 (9.6)
Feed /retentate fitting   Female luer Female luer ½ in. sanitary flange 1 in. sanitary flange 1 in. sanitary flange
-Outer diameter G NA (2) NA 25 (1.0) 50 (2.0) 50 (2.0)
-Inner diameter H NA NA 11 (0.4) 22 (0.9) 22 (0.9)
Permeate fitting   Female luer Female luer ½ in. sanitary flange 3⁄4 in. sanitary flange 3⁄4 in. sanitary flange
-Outer diameter J NA NA 25 (1.0) 25 (1.0) 25 (1.0)
-Inner diameter K NA NA 10 (0.4) 16 (0.6) 16 (0.6)
Retentate port location L 175 (6.9) 175 (6.9) 177 (7.0) 182 (7.2) 182 (7.2)
Retentate port location M 20 (0.8) 20 (0.8) 20 (0.8) 18 (0.7) 18 (0.7)
Retentate port location N 11 (0.4) 11 (0.4) 9 (0.3) 13 (0.5) 13 (0.5)
Permeate port location P 169 (6.7) 169 (6.7) 168 (6.6) 161 (6.3) 161 (6.3)
Permeate port location Q 20 (0.8) 20 (0.8) 23 (0.9) 28 (1.1) 28 (1.1)
Permeate port location R 11 (0.4) 11 (0.4) 9 (0.4) 15 (0.6) 15 (0.6)
Notch diameter S 10 (0.4) 10 (0.4) 10 (0.4) 16 (0.6) 16 (0.6)
Notch locations T 13 (0.5) 13 (0.5) 13 (0.5) 89 (3.5) 89 (3.5)
Notch locations U 24 (1.0) 24 (1.0) 24 (1.0) 49 (1.9) 49 (1.9)
 
(1)xxx is corresponding to the nominal molecular weight cutoff code: 010 for 10 kDa, 030 for 30 kDa, 100 for 100 kDa (see ordering information)
(2) NA = Not applicable


The dimensions provided are nominal. Actual dimensions may vary slightly.

Dimensional Drawings


Applications

Typical applications for Cadence single-use TFF modules are in the downstream processing operations for the concentration and/or diafiltration of biological products in the biotech and vaccines industries.
Cadence single-use TFF modules can be implemented from R&D lab to commercial production. Fully scalable, the drug product development and validation steps can be streamlined.
Purpose-designed for single-use, they are especially recommended for multipurpose facilities or contract manufacturing organizations (CMOs), for clinical material or for commercial production with batch sizes up to several hundred liters.

Performance

Integrity Testing

 
Parameter Value
Test pressure 2 barg (30 psig)
Maximum air Forward Flow ≤ 1600 mL/min/m²
(≤ 150 mL/min/ft²) at 20°C
 

Type

TFF Cassettes and Modules

Use

Tangential Flow Filtration

Ordering Information

Pall’s Cadence SUTFF Modules
 
Part Number Description Format Nominal Molecular Weight Cutoff (NMWC) Effective Membrane Filtration Area (EFA)
CSUM010T001 Cadence single-use TTF modules with Omega membrane Centramate™ 10 kDa 93 cm2 (0.1 ft2)
CSUM010T002 Centramate 186 cm2 (0.2 ft2)
CSUM010T010 Centramate 0.1 m2 (1.1 ft2)
CSUM010T050 Centrasette™ 0.5 m2 (5.4 ft2)
CSUM010T250 Centrasette 2.5 m2 (27 ft2)
CSUM030T001 Centramate 30 kDa 93 cm2 (0.1 ft2)
CSUM030T002 Centramate 186 cm2 (0.2 ft2)
CSUM030T010 Centramate 0.1 m2 (1.1 ft2)
CSUM030T050 Centrasette 0.5 m2 (5.4 ft2)
CSUM030T250 Centrasette 2.5 m2 (27 ft2)
CSUM100T001 Centramate 100 kDa 93 cm2 (0.1 ft2)
CSUM100T002 Centramate 186 cm2 (0.2 ft2)
CSUM100T010 Centramate 0.1 m2 (1.1 ft2)
CSUM100T050 Centrasette 0.5 m2 (5.4 ft2)
CSUM100T250 Centrasette 2.5 m2 (27 ft2)
 


Holders for Pall’s Cadence SUTFF Modules
 
Holder Part Number CSUH040 CSUH250SA
Format of compatible Cadence SUTFF modules Centramate Centrasette
Orientation: vertical or horizontal Both Horizontal
Part numbers of compatible Cadence SUTFF module CSUM010T001 CSUM010T050
CSUM010T002 CSUM010T250
CSUM010T010 CSUM030T050
CSUM030T001 CSUM030T250
CSUM030T002 CSUM100T050
CSUM030T010 CSUM100T250
CSUM100T001 -
CSUM100T002 -
CSUM100T010 -
Number of Cadence SUTFF modules that fit in holder 1 1
 

In addition to Cadence single-use cassette modules, Pall’s TFF module holders can also accommodate standard cassettes when used with single-use distribution manifolds as the end plates. Please contact your Pall representative for more information about the maximum number and types of cassettes that can be accommodated, or about the use of standard cassettes in Pall’s TFF module holders.

Product Summary

Ready-to-use, single-use TFF modules designed for use in Allegro™ single-use TFF systems or for integrattion into other single-use TFF set-ups

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