Microza* Membranes - Polysulfone product photo Primary L

Microza* Membranes - Polysulfone

Polymeric Membrane Morphology

Microza* ultrafiltration membranes are unique in their construction. Every membrane has an asymmetric structure,with a membrane layer both on the inside, and on the outside of the fiber, overlaying a core comprising a very open support for excellent flow characteristics, and a central strengthening layer for outstanding fiber durability in long-term service. These ultrafiltration membranes are resistant to flow in both directions, so there is no risk of delamination or membrane rupture during accidental back-pressure. In fact, in many installations, backpulsing can be used to maintain flux during extended run times.

These micofiltration membranes have smooth inner and outer membrane skins with a highly porous symmetrical support structure giving high-flow rates. These modules can also be backflushed.

All the membranes have surfaces that minimize entrapment and facilitate cleaning and the membranes are manufactured in a single step, and are not composed of laminates. Membranes and modules are subjected to rigorous quality control to ensure consistency of performance, durability in service, and module integrity for the most demanding applications.

Polysulfone (PS)

Polysulfone membranes exhibit excellent resistance to pressure, temperature and aggressive cleaning regimes. Very low affinity and adsorption characteristics results in high product recoveries, and long service life.

The SP, SV and VP series hollow fiber ultrafiltration modules have a unique double-skinned proprietary polysulfone (PS) membrane with dense internal layer. Currently available in 3000, 4000, 6000, and 10000 molecular weight cut-offs, the modules are used in a range of pharmaceutical applications including pyrogen removal from water, buffer solutions active ingredients such as antibiotics, and concentration of protein solutions. SV modules are used for clarifying antibiotic and other broths used for small molecule active pharmaceuticals ingredients production.

Key Features 

  • Combination of high-strength and high-flow due to unique membrane construction
  • Double-skin provides assurance of removal rating
  • High-strength fiber allows reverse filtration to assist cleaning in difficult applications
  • Available in a range of sizes from 0.015 m2 (0.16 ft2) to more than 12 m2 (125 ft2)
  • All SP and VP modules may be hot water sanitized: up to 95 °C – SIP and SLP, or 90 °C – SEP and SAP; and all may run continuously at 80 °C
  • SP Modules may be autoclaved in single use applications
  • VIP 6000 MWCO version steam-sterilizable up to 50 cycles at 125 °C at a differential pressure of 100 mbar
  • SV modules are designed for maximized recovery in bulk fermentation, limited to 50 °C
  • Compatible with a wide range of cleaning agents, up to 5000 ppm sodium hypochlorite or 4% sodium hydroxide
  • Meets the specification for biological tests listed in the current revision of USP for class VI plastics at 121 °C
  • pH range 1 – 14

Microza Module Types

The hollow fiber modules are available with housings made from polysulfone (native, clear), filled polysulfone (white, opaque), and polyvinylchloride (PVC). Polysulfone modules will withstand autoclaving and in some cases steaming. Clear polysulfone modules are recommended for more critical pharmaceutical applications. Filled polysulfone and PVC modules are ideally suited to long term installations where light might cause biofilm to form, or for bulk processes involving light sensitive materials. PVC modules are idea for use in feed water systems and bulk processes.

These modules are available with industry standard clamp fittings on the feed and retentate side, and some with quick connects. All steamable modules designed for long term use in critical applications such as perfusion have sanitary clamp connections on the feed/retentate and filtrate sides, or filtrate hose barbs on laboratory scale modules.

Retrofitting Existing Applications

To retrofit an existing application,membrane rating should be chosen to be equivalent or superior in performance. For ultrafiltration membranes, this may require testing more than a single cut-off. Differences in membrane area and lumen diameter can typically be accommodated by adjustments to operating conditions to ensure that trans-membrane pressure and fluid velocity conditions at the membrane surface are similar. Hollow fiber modules can be joined end-to-end as required to create similar path length systems. Small adjustments to physical dimensions, and differences in connection type are accomplished using adapters. Please contact Pall for assistance with selecting the right modules to retrofit an existing installation.

* Microza is a trademark of Asahi Kasei Corporation



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Description

Polymeric Membrane Morphology

Microza* ultrafiltration membranes are unique in their construction. Every membrane has an asymmetric structure,with a membrane layer both on the inside, and on the outside of the fiber, overlaying a core comprising a very open support for excellent flow characteristics, and a central strengthening layer for outstanding fiber durability in long-term service. These ultrafiltration membranes are resistant to flow in both directions, so there is no risk of delamination or membrane rupture during accidental back-pressure. In fact, in many installations, backpulsing can be used to maintain flux during extended run times.

These micofiltration membranes have smooth inner and outer membrane skins with a highly porous symmetrical support structure giving high-flow rates. These modules can also be backflushed.

All the membranes have surfaces that minimize entrapment and facilitate cleaning and the membranes are manufactured in a single step, and are not composed of laminates. Membranes and modules are subjected to rigorous quality control to ensure consistency of performance, durability in service, and module integrity for the most demanding applications.

Polysulfone (PS)

Polysulfone membranes exhibit excellent resistance to pressure, temperature and aggressive cleaning regimes. Very low affinity and adsorption characteristics results in high product recoveries, and long service life.

The SP, SV and VP series hollow fiber ultrafiltration modules have a unique double-skinned proprietary polysulfone (PS) membrane with dense internal layer. Currently available in 3000, 4000, 6000, and 10000 molecular weight cut-offs, the modules are used in a range of pharmaceutical applications including pyrogen removal from water, buffer solutions active ingredients such as antibiotics, and concentration of protein solutions. SV modules are used for clarifying antibiotic and other broths used for small molecule active pharmaceuticals ingredients production.

Key Features 

  • Combination of high-strength and high-flow due to unique membrane construction
  • Double-skin provides assurance of removal rating
  • High-strength fiber allows reverse filtration to assist cleaning in difficult applications
  • Available in a range of sizes from 0.015 m2 (0.16 ft2) to more than 12 m2 (125 ft2)
  • All SP and VP modules may be hot water sanitized: up to 95 °C – SIP and SLP, or 90 °C – SEP and SAP; and all may run continuously at 80 °C
  • SP Modules may be autoclaved in single use applications
  • VIP 6000 MWCO version steam-sterilizable up to 50 cycles at 125 °C at a differential pressure of 100 mbar
  • SV modules are designed for maximized recovery in bulk fermentation, limited to 50 °C
  • Compatible with a wide range of cleaning agents, up to 5000 ppm sodium hypochlorite or 4% sodium hydroxide
  • Meets the specification for biological tests listed in the current revision of USP for class VI plastics at 121 °C
  • pH range 1 – 14

Microza Module Types

The hollow fiber modules are available with housings made from polysulfone (native, clear), filled polysulfone (white, opaque), and polyvinylchloride (PVC). Polysulfone modules will withstand autoclaving and in some cases steaming. Clear polysulfone modules are recommended for more critical pharmaceutical applications. Filled polysulfone and PVC modules are ideally suited to long term installations where light might cause biofilm to form, or for bulk processes involving light sensitive materials. PVC modules are idea for use in feed water systems and bulk processes.

These modules are available with industry standard clamp fittings on the feed and retentate side, and some with quick connects. All steamable modules designed for long term use in critical applications such as perfusion have sanitary clamp connections on the feed/retentate and filtrate sides, or filtrate hose barbs on laboratory scale modules.

Retrofitting Existing Applications

To retrofit an existing application,membrane rating should be chosen to be equivalent or superior in performance. For ultrafiltration membranes, this may require testing more than a single cut-off. Differences in membrane area and lumen diameter can typically be accommodated by adjustments to operating conditions to ensure that trans-membrane pressure and fluid velocity conditions at the membrane surface are similar. Hollow fiber modules can be joined end-to-end as required to create similar path length systems. Small adjustments to physical dimensions, and differences in connection type are accomplished using adapters. Please contact Pall for assistance with selecting the right modules to retrofit an existing installation.

* Microza is a trademark of Asahi Kasei Corporation

Specifications

Materials of Construction

 
Membrane Polysulfone (with silicone coating on ends in VIP–3017S)
Housing Native clear polysulfone (P) or PVC (V)
Potting Material Epoxy Resin
Gasket Silicone (P) or butyl rubber (NBR) (V)
Bacteriostat Glycerin 65%, Ethanol 2%, water balance
 

Connectors and Adapters

 
A - A1 Small hose barb 4.5 mm (3/16 in.)
A2 Small hose barb 6 mm (¼ in)
B - B1

Quick connect -To convert feed/retentate to:
1½ in. sanitary clamp, order part number 0450163 (fits in body of module)
¼ in. sanitary clamp, order part number 2055675 (fits in body of module)
¼ in. hosebarb (fits on quick-connect) order part number 2055999 (polypropylene)
¼ in. FNPT (fits on quick-connect) order part number 2089150 (316L stainless steel)

C - C3 1 in. sanitary flange (ferrule face 34 mm [1.34 in.]) 
C4 1½ in. sanitary flange (ferrule face 50 mm [1.98 in.]) 
C5 2 in. sanitary flange (ferrule face 64 mm [2.52 in.])  
C7 4 in. sanitary flange (ferrule face 117 mm [4.61 in.])  
C8 6 in. sanitary flange (ferrule face 157 mm [6.18 in.])  
D - D2 Cap nut, 38.5 mm diameter
D3 Cap nut, 48.5 mm diameter
 

Part Numbers and Technical Specification - Table 1 1

 
Part Number Rating
(MWCO, Daltons)
Fiber ID / OD Nominal Length (2)
(mm)
Membrane Area
(m2)
Clean Water Flux
Lh-1 bar, 25 oC
Crossflow Rate for 1ms-1 fluid velocity
SEP-0013 3000 0.7 / 1.3 mm 130 0.017 2.2 181
SEP-1013 3000 0.8 / 1.4 mm  347 0.19 25 724
SEP-2013 3000 0.8 / 1.4 mm   552 1.0 130 1629
SEP-3013 3000 0.8 / 1.4 mm  1129 4.7 650 3655
SAP-0013 4000 0.7/ 13 mm  130 0.017 3.6 181
SAP-1013 4000 0.8 / 1.4 mm  347 0.19 36 724
SAP-3013 4000 0.8 / 1.4 mm  1129 4.7 900 3655
SAV-3013 4000 0.8 / 1.4 mm  1126 5.6 1100 4343
SAV-5013 4000 0.8 / 1.4 mm  1126 12.1 2400 9950
SIP-0013 6000 0.8 / 1.4 mm  130 0.017 3.4 181
SIP-1013 6000 0.8 / 1.4 mm  347 0.19 40 724
SIP-1023 6000 0.8 / 1.1 mm  347 0.19 44 724
SIP-2013 6000 0.8 / 1.4 mm  552 1.0 200 1629
SIP-3013 6000 0.8 / 1.4 mm  1129 4.7 1000 3655
SIP-3023 6000 0.8 / 1.1 mm  1129 7.2 1700 5610
VIP-3017S(4) 6000 0.8 / 1.4 mm   1129 4.7 1000 3655
SLP-0053 10000 1.4 / 2.3 mm  130 0.015 4.1 277
SLP-1053 10000 1.4 / 2.3 mm  347 0.12 40 776
SLP-2053 10000 1.4 / 2.3 mm  552 0.6 150 1773
 SLP-3053 10000 1.4 / 2.3 mm  1129 4.5 1500 5819
 

Part Numbers and Technical Specification - Table 2 1

 
Part Number Maximum Pressure (barg) Feed/TMP/Permeate at 50 oC Volume Feed Side (3) (mL) Volume Permeate Side (3)  (mL) Feed/Retentate Connection Permeate Connection
SEP-0013 1/1/1 9 9 A2 A1
SEP-1013 3/3/2 90 120 B1 B1
SEP-2013 5/3/2 300 500 C4 C3
SEP-3013 5/3/3 1200 3700 C5 C4
SAP-0013 1/1/1 9 9 A2 A1
SAP-1013 3/3/2 90 120 B1 B1
SAP-3013 5/3/3 1200 3700 C5 C4
SAV-3013 5/3/3 1200 3700 C7 D2
SAV-5013 5/3/3 3800 5300 C8 D3
SIP-0013 1/1/1 9 9 A2 A1
SIP-1013 3/3/2 90 120 B1 B1
SIP-1023 3/3/2 90 130 B1

B1

SIP-2013 5/3/2 300 500 C4 C3
SIP-3013 5/3/3 1200 3700 C5 C4
SIP-3023 5/3/3 700 3700 C5 C4
VIP-3017S(4) 5/3/3 1200 3700 C5 C4
SLP-0053 1/1/1 11 9 A2 A1
SLP-1053 3/3/2 85 120 B1 B1
SLP-2053 5/3/2 310 500 C4 C3
SLP-3053 5/3/3 1850 3700 C5 C4
 
(1) Third letter represents housing material: P - Clear native Polysulfone with silicone gasket, V - white (gray- LGV, LOV) PVC butyl rubber gasket
(2) Nominal length is flange to flange, or to ends of connectors on quick-connect modules. Detailed drawings available upon request.
(3) Guideline module filling volume to allow calculation of minimum system working volumes when added to volumes of attached piping and other components. Draining residual volumes are considerably less.
(4) VIP-3017S - Maximum inlet pressure for steam at 121 oC is 1.1 barg, max TMP 0.1 barg, filtrate pressure ) (open steaming, no back pressure)

Ordering Information
For ordering information, please see table under 'Specifications' tab.
Application
Membranes
Segment
Tangential Flow Filtration