Polymeric Membrane MorphologyMicroza* ultrafiltration membranes are unique in their construction. Every membrane has an asymmetric structure,with a membrane layer both on the inside, and on the outside of the fiber, overlaying a core comprising a very open support for excellent flow characteristics, and a central strengthening layer for outstanding fiber durability in long-term service. Microza ultrafiltration membranes are resistant to flow in both directions, so there is no risk of delamination or membrane rupture during accidental back-pressure. In fact, in many installations, backpulsing can be used to maintain flux during extended run times.
Microza micofiltration membranes have smooth inner and outer membrane skins with a highly porous symmetrical support structure giving high-flow rates. These modules can also be backflushed.
All Microza membranes have surfaces that minimize entrapment and facilitate cleaning. All Microza membranes are manufactured in a single step, and are not composed of laminates. Membranes and modules are subjected to rigorous quality control to ensure consistency of performance, durability in service, and module integrity for the most demanding applications.
Polyvinylidenefluoride (PVDF)PVDF membranes are widely used for the filtration of biological solutions. In hollow fiber format, these membranes show excellent retention characteristics, allowing use in critical applications where absolute removal over long periods is required. Lower non-specific binding than many PS membranes used in protein recovery applications ensures excellent results in leading-edge biotechnology processes. PVDF membranes are steamable in situ for additional process security. PVDF exhibits superior chemical resistance to many other polymers used in microfiltration processes.
The U series of Microza hollow fiber microfiltration modules feature unique proprietary membranes in specially resistant PVDF for microfiltration applications. Available in 0.2 µm (UM series) and 0.65 µm (UJ series) rating, the modules are used in a range of pharmaceutical applications especially in cell harvesting, perfusion cell culture, viral vector production, and clarification of microbial extracts.
- Low non-specific protein binding for long term flux maintenance in cell culture applications
- Available different fiber diameters allows optimization to different particulate or colloidal loadings
- Superior chemical resistance of Microza PVDF ensures compatibility in a broad range of processing and cleaning applications
- Highly characterized,optimized void structure ensures reproducible separation efficiency and high throughput
- High-strength fiber allows reverse filtration to optimize yield and performance in difficult applications
- Available in a range of sizes from 0.02 m2 (0.21 ft2) to 5 m2 (54 ft2)
- U series can operate continuously in processes up to 80 °C and may be steamed in situ at 125 °C for 20 cycles
- Meets the specification for biological tests listed in the current revision of USP for Class VI plastics at 121 °C
- pH 2 – 10
Microza Module TypesMicroza hollow fiber modules are available with housings made from polysulfone (native, clear), filled polysulfone (white, opaque), and polyvinylchloride (PVC). Polysulfone modules will withstand autoclaving and in some cases steaming. Clear polysulfone modules are recommended for more critical pharmaceutical applications. Filled polysulfone and PVC modules are ideally suited to long term installations where light might cause biofilm to form, or for bulk processes involving light sensitive materials. PVC modules are idea for use in feed water systems and bulk processes.
Microza modules are available with industry standard clamp fittings on the feed and retentate side, and some with quick connects. All steamable modules designed for long term use in critical applications such as perfusion have sanitary clamp connections on the feed/retentate and filtrate sides, or filtrate hose barbs on laboratory scale modules.
Retrofitting Existing ApplicationsTo retrofit an existing application,membrane rating should be chosen to be equivalent or superior in performance. For ultrafiltration membranes, this may require testing more than a single cut-off. Differences in membrane area and lumen diameter can typically be accommodated by adjustments to operating conditions to ensure that trans-membrane pressure and fluid velocity conditions at the membrane surface are similar. Hollow fiber modules can be joined end-to-end as required to create similar path length systems. Small adjustments to physical dimensions, and differences in connection type are accomplished using adapters. Please contact Pall for assistance with selecting the right modules to retrofit an existing installation.
* Microza is a trademark of Asahi Kasei Corporation
Materials of Construction
|Housing||Native clear polysulfone (P) or filled polysulfone (W)|
|Potting Material||Epoxy Resin|
|Bacteriostat||Glycerin 65%, Ethanol 2%, water balance|
Connectors and Adapters
|A - A1||Small hose barb 4.5 mm (3/16 in.)|
|A2||Small hose barb 6 mm (¼ in)|
|B - B1|| |
Quick connect -To convert feed/retentate to:
|C - C3||1 in. sanitary flange (ferrule face 34 mm [1.34 in.])|
|C4||1½ in. sanitary flange (ferrule face 50 mm [1.98 in.])|
|C5||2 in. sanitary flange (ferrule face 64 mm [2.52 in.])|
|C7||4 in. sanitary flange (ferrule face 117 mm [4.61 in.])|
|C8||6 in. sanitary flange (ferrule face 157 mm [6.18 in.])|
|D - D2||Cap nut, 38.5 mm diameter|
|D3||Cap nut, 48.5 mm diameter|
Part Numbers and Technical Specification - Table 1 1
|Part Number||Rating |
|Fiber ID / OD||Nominal Length (2) |
|Membrane Area |
|Clean Water Flux |
Lh-1 bar , 25 oC
|Crossflow Rate for 1ms-1 |
|UMP-053||0.2||2.6 / 4.1 mm||130||0.015||1.5||287|
|UMP-153||0.2||2.6 / 4.1 mm||347||0.08||8||956|
|UMP-353||0.2||2.6 / 4.1 mm||1129||2.2||200||5161|
|UMW-553||0.2||2.6 / 4.1 mm||1172||5.0||500||12424|
|UMP-0047R||0.2||1.4 / 2.2 mm||310||0.02||19||116|
|UMP-1047R||0.2||1.4 / 2.2 mm||320||0.09||80||554|
|UMP-1147M||0.2||1.4 / 2.2 mm||550||0.33||330||953|
|UMP-1147R||0.2||1.4 / 2.2 mm||550||0.19||180||554|
|UMP-2147R||0.2||1.4 / 2.2 mm||546||0.77||750||2216|
|UMP-3147R||0.2||1.4 / 2.2 mm||630||2.0||2000||-|
|UMP-3247R||0.2||1.4 / 2.2 mm||1129||4.0||4000||-|
|UJP-1047R||0.65||1.1 / 2.0 mm||546||0.02||120||462|
|UJP-1147M||0.65||1.1 / 2.0 mm||546||0.32||380||708|
|UJP-1147R||0.65||1.1 / 2.0 mm||546||0.19||230||428|
|UJP-2147R||0.65||1.1 / 2.0 mm||546||0.73||850||1625|
|UJP-3147R||0.65||1.1 / 2.0 mm||630||1.9||2300||-|
|UJP-3247R||0.65||1.1 / 2.0 mm||1129||3.8||4600||-|
Part Numbers and Technical Specification - Table 2 1
|Part Number|| |
Maximum Pressure (barg) Feed/TMP/Permeate at 50 oC
|Volume Feed Side (3)||Volume Permeate Side (3) (mL)||Feed/Retentate Connection||Permeate Connection|
(2) Nominal length is flange to flange, or to ends of connectors on quick-connect modules. Detailed drawings available upon request.
(3) Guideline module filling volume to allow calculation of minimum system working volumes when added to volumes of attached piping and other components. Draining residual volumes are considerably less.