Pall Microdisc Capsules with Pegasus™ Protect Virus Prefilter Membrane
Capsules
Protecting Critical Virus Filtration
Variations between bioprocesses lead to virus filter feed streams with varying fouling characteristics. Where these feeds are observed to foul virus filters this can lead to extended process times or increased filter sizing.
Pall Pegasus Protect virus prefiltration membrane is tailored to provide protection to Pegasus Prime virus filters and to deliver the highest level of robust filter performance in more challenging process fluids. The combination of Pegasus Protect and Pegasus Prime filters increases throughput and leads to a reduction in processing costs by a reduction in virus filter sizing and processing times.
The Microdisc capsules containing Pegasus Protect media are optimized for the confirmation and validation of performance at a small scale using minimal volumes of process fluid.
Performance established during small scale trials can be easily scaled as both Pegasus Protect prefilters and Pegasus Prime virus filters are available in a range of optimized capsule and filter formats which maintain a constant area ratio between prefiltration and virus filtration at all scales.
All process scale devices can be integrated into single-use and automated solutions to offer the highest degree of control, flexibility and security.
Features and Benefits
| Removes filter plugging substances virus filters | Reduce plugging of Pegasus Prime
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| The scale-up range provides a consistent prefilter to virus filter area ratio at all scales | Consistent performance
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| Fully disposable capsule with Luer connections | Easy to use, ready to use |
Filter Membrane: Nylon
Housing, Vent Plug and Support: Polypropylene
Retention Ratings
Pore size : 0.2 μm nominal
Effective Filter Area (EFA) (Nominal)
3.9 cm2
Operating Parameters
Maximum Temperature: 40 °C
Maximum Pressure: 3.1 bar (45 psi)*
Maximum Differential Pressure: 3.1 bar (45 psi)*
*up to 12 hours at 25 °C; up to 6 hours at 40 °C
Recommended Operating Conditions
35 mbard (0.5 psid) or 2 mL/min water at 20 °C*
*when used with Pegasus Prime Microdisc capsules
Typical Hold-Up Volume (with air purge)
< 125 μL
Dimensions (Nominal)
Length: 2.0 cm (0.8 in.)
Diameter : 3.0 cm (1.2 in.)
Connection Type
Female Luer-Lock inlet, male slip Luer outlet
Impact of Pegasus Protect Prefiltration on Required Virus Flters Per Batch
Scalable Solutions
Prefiltration area and flowrate are critical variables that may affect the performance of Pegasus Protect prefiltration and Pegasus Prime virus removal filters when used in combination.
To control these variables Pegasus Protect prefiltration media is available in a range of formats, designed to maintain a consistent pre-filter to virus-filter ratio. This control ensures predictable and consistent performance at all scales from the initial Microdisc scale trials to clinical manufacturing.
| Area | Microdisc Capsules | Area | Kleenpak / Mini Kleenpak Capsules | |
| Pegasus Protect Prefiltration | 3.9 cm2 |  | 286 cm2 |  |
| Pegasus Prime Virus Filter | 2.8 cm2 | 204 cm2 | ||
| Area ratio | 1.4 : 1 | 1.4 : 1 | ||
Ordering Information | ||
| Part Number | Description | Pkg |
| 4MCFPRT4 | Pall Microdisc Capsules with Pegasus Protect Filter Membrane | 4/box |
| 4MCFPRT12 | Pall Microdisc Capsules with Pegasus Protect Filter Membrane | 12/box (4 x 3 lots) |
Pegasus Prime Virus Removal Filters | ||
| 3MCFPRM4 | Pall Microdisc Capsules with Pegasus Protect Filter Membrane | 4/box |
| 3MCFPRM12 | Pall Microdisc Capsules with Pegasus Protect Filter Membrane | 12/box (4 x 3 lots) |
Accessories | ||
| C3EP1 | Pall NovaSip™ empty capsule for use as a single-use pressure reservoir | 1/pkg |
