Pall Filter Cartridges and Kleenpak™ Nova Capsules with Pegasus™ Protect Virus Prefilter Membrane product photo Primary L

Pall Filter Cartridges and Kleenpak™ Nova Capsules with Pegasus™ Protect Virus Prefilter Membrane

Process-Scale Virus Filter Prefiltration

Pall Pegasus Protect virus prefiltration membrane is tailored to provide protection to Pegasus Prime virus filters and to deliver the highest level of robust filter performance in more challenging process fluids. The combination of Pegasus Protect and Pegasus Prime filters increases throughput and leads to a reduction in processing costs through a reduction in virus filter sizing and processing times.

The range of process-scale filter cartridges and capsules containing Pegasus Protect prefiltration media is designed to maintain a constant area ratio between prefiltration and virus filtration at all scales and are optimized for use with filter cartridges and capsules containing Pegasus Prime virus removal membrane.

Features and Benefits

 
Removes filter plugging substances Reduce plugging of Pegasus Prime virus filters
  • Smaller virus filter sizing
  • Minimized cost of goods
  • Shorter processing times
  • Increased robustness to natural process fluid variation
The scale-up range provides a consistent prefilter to virus filter area ratio at all scales Consistent performance
  • Controlling scaling risks
  • Faster, simple scale-up
 


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Description

Process-Scale Virus Filter Prefiltration

Pall Pegasus Protect virus prefiltration membrane is tailored to provide protection to Pegasus Prime virus filters and to deliver the highest level of robust filter performance in more challenging process fluids. The combination of Pegasus Protect and Pegasus Prime filters increases throughput and leads to a reduction in processing costs through a reduction in virus filter sizing and processing times.

The range of process-scale filter cartridges and capsules containing Pegasus Protect prefiltration media is designed to maintain a constant area ratio between prefiltration and virus filtration at all scales and are optimized for use with filter cartridges and capsules containing Pegasus Prime virus removal membrane.

Features and Benefits

 
Removes filter plugging substances Reduce plugging of Pegasus Prime virus filters
  • Smaller virus filter sizing
  • Minimized cost of goods
  • Shorter processing times
  • Increased robustness to natural process fluid variation
The scale-up range provides a consistent prefilter to virus filter area ratio at all scales Consistent performance
  • Controlling scaling risks
  • Faster, simple scale-up
 
Specifications
 
Materials of Construction Filter Cartridges Kleenpak Nova Capsules
Filter Membrane Nylon Nylon
Support and Drainage Polyester Polyester
Endcap and adaptor Polyester Polyester
Core and cage Polypropylene Polypropylene
O-rings Silicone elastomer Silicone elastomer
Capsule hardware -- Polypropylene
Valve seals -- Silicone elastomer
 

Retention Ratings
Pore size 0.2 μm nominal
 

 
Effective Filter Area (EFA) (Nominal) 10 in. 0.7 m2
20 in. 1.4 m2
30 in. 2.1 m2
 

Operating Parameters
Maximum Temperature 40 °C 40 °C
Maximum Pressure 5.4 bar (76 psi) at 20 °C 5.4 bar (76 psi) at 20 °C
3.0 bar (43.5 psi) at 40 °C
Maximum Differential Pressure 5.4 bar (76 psi) at 20 °C 3.0 bar (43.5 psi) at 40 °C
 

 
Recommended Operating Conditions 73 mbard (1.1 psid) or 7.3 L/min/10 in.*
 
* when used with filter cartridges or Kleenpak Nova capsules with Pegasus Prime virus removal media at 2.1 bard (30 psid)

 
Steam Autoclaving
Cumulative autoclave time 16 hours at 125 °C*
4 hours at 140 °C
 
*laboratory tests (1-hour cycles). Contact Pall for recommended procedures
WARNING: Kleenpak capsules must not be steam sterilized in-situ by passing steam through under pressure

 
Dimensions(Nominal) Filter Cartridges Kleenpak Nova Capsules
In-Line T-Style
Length 254 mm(10 in.)
508 mm(20 in.)
762 mm(30 in.)
335 mm(13.2 in.)
584 mm(23.0 in.)
834 mm(32.8 in.)
349 mm(13.7 in.)
598 mm(23.5 in.)
848 mm(33.4 in.)
Diameter including n/a 154 mm(6.1 in.) 240 mm(9.5 in.)
Connection Type n/a 1 in. sanitary flange
 
Performance
Figure 1
Impact of Pegasus Protect Prefiltration on Required Virus Flters Per Batch

Scalable Solutions

Prefiltration area and flowrate are critical variables that may affect the throughput of Pegasus Protect prefiltration and Pegasus Prime virus removal filters when used in combination.

To control these variables Pegasus Protect prefiltration media is available in a range of formats designed to maintain a consistent prefilter to virus filter ratio. This control ensures predictable and consistent performance at all scales from the initial Microdisc scale trials to large-scale clinical manufacturing.

 
  Lab Scale Development Scale Full Scale
    Area   Area   Area
Pegasus Protect Prefiltration Microdisc 3.9 cm2 Kleenpak 286 cm2 20 in. Kleenpak Nova 1.4 m2
Pegasus Prime Virus Filtration  Microdisc 2.8 cm2 Mini Kleenpak 205 cm2 10 in. Kleenpak Nova 1 m2
    1.4 : 1   1.4 : 1   1.4 : 1
 
Ordering Information
 
Part Number Description Pkg
AB1PRT7PH4 Pall 254 mm (10 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 0.7 m2 1/pkg
N*6PRTP1 Pall 254 mm (10 in.) Kleenpak Nova filter capsules with Pegasus Protect prefiltration membrane. Nominal area 0.7 m2 1/pkg
AB2PRT7PH4 Pall 508 mm (20 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 1.4 m2 1/pkg
N*7PRTP1 Pall 508 mm (20 in.) Kleenpak Nova filter capsules with Pegasus Protect prefiltration membrane. Nominal area 1.4 m2 1/pkg
AB3PRT7PH4 Pall 762 mm (30 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 2.1 m2 1/pkg
N*8PRTP1 Pall 762 mm (30 in.) Kleenpak Nova filter capsules with Pegasus Protect prefiltration membrane. Nominal area 2.1 m2 1/pkg
 
* [P] – In-line flow / [T] - T-style flow

Scale-down Devices
4MCFPRT4 Pall Microdisc Capsules with Pegasus Protect filter membrane 4/box
4MCFPRT12 Pall Microdisc Capsules with Pegasus Protect filter membrane 12/box(4 x 3 lots)
KA1PRTP18FT Pall Kleenpak filterability tool with Pegasus Protect prefiltration media  
 

Pegasus Prime Virus Removal Filters
Part Number Description Pkg
AB1UPRM7PH4 Pall 254 mm (10 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 1 m2 1/pkg
N*6LUPRMP1 Pall 254 mm (10 in.) Kleenpak Nova filter capsules with Pegasus Protect prefiltration membrane. Nominal area 1 m2 1/pkg
AB2UPRM7PH4 Pall 508 mm (20 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 2 m2 1/pkg
N*7LUPRMP1 Pall 508 mm (20 in.) Kleenpak Nova filter Pegasus Protect prefiltration membrane. Nominal area 2 m2 1/pkg
AB3UPRM7PH4 Pall 762 mm (30 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 3 m2 1/pkg
N*8LUPRMP1 Pall 762 mm (30 in.) Kleenpak Nova filter capsules with Pegasus Protect prefiltration membrane. Nominal area 3 m2 1/pkg
 
* [P] – In-line flow / [T] - T-style flow