Pegasus™ SV4 Virus Removal Membrane Filter Discs product photo Primary L

Pegasus™ SV4 Virus Removal Membrane Filter Discs

Compact, Easily-scalable Filter Discs for Virus Removal and Small-scale Membrane Qualification Studies

Pegasus SV4 Virus Removal filters combine robust, high viral clearance of parvovirus and larger viruses with high throughput capacity and stable flowrates, in both dilute and complex concentrated biological fluids. Consistent flowrates and throughput performance provide superior control of process costs and maximizes virus filtration economy and efficiency.

Pegasus SV4 Virus Removal Membrane Filter Discs are purpose-designed for small-scale membrane qualification studies such as bacteriophage or prion (TSE agent) clearance, as well as membrane flow rate, capacity and protein transmission studies. Filter discs are lot sample tested and manufactured under a Quality Management System certified to ISO 9001:2008 in order to assure consistently high quality.

 
Features Benefits
Pegasus SV4 virus removal filter membrane Robust, high > 4 LRV parvovirus clearance
Constant flow and high throughput performance Maximize virus filter process economy and efficiency
Identical membrane to larger production scale Pegasus SV4 virus filter cartridges Offers reliable scalability
Used in Pall FTK-200 disc holder Easy handling
Individual membrane box identified by lot number Complete traceability of manufacturing history
Manufacturing lot sample tested Assurance of consistently high quality
Membrane bacteriophage tested Assurance of consistently high quality
Pre- and post-use installation testable Assurance of consistently high quality at point of use
Low protein-binding High protein recovery
Robust membrane with high viral clearance and resistance to plugging Flow decay minimized at high virus spike concentrations and with complex or concentrated feeds
 

Materials

  • Filter fluid path components have met the specifications under Section <88> Biological Reactivity Tests in vivo listed in the current revision of the United States Pharmacopeia (USP) for Class VI plastics at 121 °C.


* Required
Need Help?
Download Datasheet
Description

Compact, Easily-scalable Filter Discs for Virus Removal and Small-scale Membrane Qualification Studies

Pegasus SV4 Virus Removal filters combine robust, high viral clearance of parvovirus and larger viruses with high throughput capacity and stable flowrates, in both dilute and complex concentrated biological fluids. Consistent flowrates and throughput performance provide superior control of process costs and maximizes virus filtration economy and efficiency.

Pegasus SV4 Virus Removal Membrane Filter Discs are purpose-designed for small-scale membrane qualification studies such as bacteriophage or prion (TSE agent) clearance, as well as membrane flow rate, capacity and protein transmission studies. Filter discs are lot sample tested and manufactured under a Quality Management System certified to ISO 9001:2008 in order to assure consistently high quality.

 
Features Benefits
Pegasus SV4 virus removal filter membrane Robust, high > 4 LRV parvovirus clearance
Constant flow and high throughput performance Maximize virus filter process economy and efficiency
Identical membrane to larger production scale Pegasus SV4 virus filter cartridges Offers reliable scalability
Used in Pall FTK-200 disc holder Easy handling
Individual membrane box identified by lot number Complete traceability of manufacturing history
Manufacturing lot sample tested Assurance of consistently high quality
Membrane bacteriophage tested Assurance of consistently high quality
Pre- and post-use installation testable Assurance of consistently high quality at point of use
Low protein-binding High protein recovery
Robust membrane with high viral clearance and resistance to plugging Flow decay minimized at high virus spike concentrations and with complex or concentrated feeds
 

Materials

  • Filter fluid path components have met the specifications under Section <88> Biological Reactivity Tests in vivo listed in the current revision of the United States Pharmacopeia (USP) for Class VI plastics at 121 °C.
Specifications

Technical Data

Materials of Construction

 
Item Material
Membrane Hydrophilic modified polyvinylidene fluoride (PVDF)
Support Disc Polypropylene (Non-woven)
O-ring (Disc Holder) EPDM
Disc Holder Stainless steel
 

Pore size

 
20 nm (nominal)
 

Retention Ratings

 
Virus
Bacteriophage PP7 > 4 log TR*†
 
* Claims based on challenge with parvovirus model bacteriophage (bacterial virus) PP7

† > 4 LRV for PP7 bacteriophage per Parenteral Drug Association (PDA) TR 41 rating method for small virus-retentive filters > 4 LRV typically with mammalian parvoviruses


 
Effective Surface Area
11.1 cm2 (1.72 in.2) in FTK-200 Disc Holder
Operating Parameters**
Recommended Temperature 4 - 45 °C
Maximum Operating Pressure 5 barg (73 psig)
Maximum Differential Pressure 4.5 bard (65 psid)
Recommended Operating Differential Pressure 2.1 – 3.1 bard
(30 – 45 psid)
 
** Maximum air/gas pressure for installation test is 6.2 barg (90 psig)
Ordering Information
 
Part Number Description
FTKSV404705 Filter Discs1
FTKSV4047025 Filter Discs2
 
1 Five discs per box, 2 Twenty-five discs per box
|
 
Part Number Holder
FTK-200 Disc Holder FTK-200
 

Further Equipment Recommended for Laboratory Testing

 
Part Number Pressure Vessels (Stainless steel)
ZLK702G23LHKH4 Sealkleen™ vessel
Part Number Accessories (Sealkleen Vessel)
GFX0290 Adapter 1 in. TC/Male Stäubli connector plug (3 mm) R 14 in.
GFX0390 Adapter 1 in. TC connector plug R 14 in. NPT (FTK-200 inlet fitting)
GFX0235 Male Stäubli connector plug (3 mm) R 14 in.
Part Number Pressure Vessels (Disposable)
C3EP1 Novasip™ vessel
Part Number Accessories (Novasip Vessel)
GFX0290 Adapter 1 in. TC/Male Stäubli connector plug (3 mm) R 14 in.
SLK1TC23H4 TC clamp + gasket silicone
 
Application
Filters - Plasma and High-Fouling mAb
Segment
Viral Clearance