Pall Microdisc Capsules with Pegasus™ Prime Virus Removal Filter Membrane product photo Primary L

Pall Microdisc Capsules with Pegasus™ Prime Virus Removal Filter Membrane

Small Virus Removal for Bioprocesses

Pegasus Protect virus prefiltration combines with Pegasus Prime virus filtration to deliver the first gamma-sterilized pre-filter & virus filter combination. Together, these simplify process development, validation and operations while saving time and delivering improved process economy.

Process developers can quickly deliver a robust, scalable virus filtration process using a minimum of sample volume, and be confident of successful virus validation. This choice supports clinical manufacturing with a solution that is easy to use and versatile to work alone or with integrated and automated single-use systems.

The Microdisc capsules containing Pegasus Prime virus media are ideal for the confirmation and validation of performance at a small scale using minimal volumes of process fluid and virus spike preparations and deliver consistently high log reduction value (LRV) irrespective of the virus validation choices.

The predicted process flow, filter capacity or virus retention established during these studies scales to a range of products available to support your process at all scales and offer the highest degree of manufacturing control, flexibility and security.

Features and Benefits

 
Robust high LRV, independent of process fluid, process parameters or validation procedure Reliable performance and assured patient safety
  • Minimized risk of validation variation or failures ensures rapid process development
Robust capacity and high flow Small filtration footprints and short process times
  • Economic processes and easy integration into automated processes
Gamma irradiated > 25 kGy Virus clearance and process performance representative of larger manufacturing scale devices.
Full scale-up range with identical membrane at all scales Reliable scalability
  • Meaningful process prediction with minimal fluid volumes
Full pre-filter scale-up range with consistent pre-filter to virus filter area ratios Control scale-up risks
  • Faster, simplified scale-up
Easy to use Luer Lock connectivity for easy testing
 


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Pegasus™ Prime membrane in Microdisc capsules, 20 nm removal rating, 2.8 cm² EFA, box of 12 product photo

Pegasus™ Prime membrane in Microdisc capsules, 20 nm removal rating, 2.8 cm² EFA, box of 12

Product ID: 3MCFPRM12
Unit of Measure
1/PAC
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
Retention Rating
20 nm µm
Effective Filtration Area (Metric)
2.8 cm²
Minimum Batch Volume
0.3 L
See All Attributes
Pegasus™ Prime membrane in Microdisc capsules, 20 nm removal rating, 2.8 cm² EFA, box of 4 product photo

Pegasus™ Prime membrane in Microdisc capsules, 20 nm removal rating, 2.8 cm² EFA, box of 4

Product ID: 3MCFPRM4
Unit of Measure
1/PAC
Min Order Qty
1
Membrane Material
Polyethersulfone (PES)
Retention Rating
20 nm µm
Effective Filtration Area (Metric)
2.8 cm²
Minimum Batch Volume
0.3 L
See All Attributes

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Datasheets

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Description

Small Virus Removal for Bioprocesses

Pegasus Protect virus prefiltration combines with Pegasus Prime virus filtration to deliver the first gamma-sterilized pre-filter & virus filter combination. Together, these simplify process development, validation and operations while saving time and delivering improved process economy.

Process developers can quickly deliver a robust, scalable virus filtration process using a minimum of sample volume, and be confident of successful virus validation. This choice supports clinical manufacturing with a solution that is easy to use and versatile to work alone or with integrated and automated single-use systems.

The Microdisc capsules containing Pegasus Prime virus media are ideal for the confirmation and validation of performance at a small scale using minimal volumes of process fluid and virus spike preparations and deliver consistently high log reduction value (LRV) irrespective of the virus validation choices.

The predicted process flow, filter capacity or virus retention established during these studies scales to a range of products available to support your process at all scales and offer the highest degree of manufacturing control, flexibility and security.

Features and Benefits

 
Robust high LRV, independent of process fluid, process parameters or validation procedure Reliable performance and assured patient safety
  • Minimized risk of validation variation or failures ensures rapid process development
Robust capacity and high flow Small filtration footprints and short process times
  • Economic processes and easy integration into automated processes
Gamma irradiated > 25 kGy Virus clearance and process performance representative of larger manufacturing scale devices.
Full scale-up range with identical membrane at all scales Reliable scalability
  • Meaningful process prediction with minimal fluid volumes
Full pre-filter scale-up range with consistent pre-filter to virus filter area ratios Control scale-up risks
  • Faster, simplified scale-up
Easy to use Luer Lock connectivity for easy testing
 

Specifications

Materials of Construction
Filter Membrane: Polyethersulfone
Capsule Hardware: Polypropylene
Support Substrate : Polyester

Retention Ratings
Pore size : 20 nm nominal
Virus: > 4 log reduction value with mammalian parvoviruses

Effective Filter Area (EFA) (Nominal)
2.8 cm2 (0.43 in.2)

Operating Parameters
Maximum Temperature: 40 °C
Maximum Pressure: 3.1 bar (45 psi)*
Maximum Differential Pressure: 3.1 bar (45 psi)*
*up to 12 hours at 25 °C; up to 6 hours at 40 °C

Shelf Life
3 years

Liquid Flow v Differential Pressure (Typical)
1.4 – 2.6 mL/min at 2.1 bard, water at 20 °C

Dimensions (Nominal)
Length: 21 mm (0.8 in.)
Diameter: 29 mm (1.2 in.)

Connection Type
Female Luer-Lock inlet, male slip Luer outlet

Performance

Pegasus Prime delivers robust, high LRV independent of process parameters, process fluid and validation choices.


Figure 1
Robust, High Virus Retention



Figure 2
Robust Virus Filter Sizing


The performance established during Microdisc filterability trials scales reliably to full scale devices as shown in Figure 3. Where intermediate scale trials to confirm the performance are required, Mini Kleenpak filterability tools are available and contain the same Pegasus Prime virus media in a low area, pleated filter configuration to minimize the volume of fluid required.


Figure 3
Robust Scaling

Type

Filter Capsules

Use

Viral Safety

Ordering Information

Ordering Information

 
Part Number Description Pkg
3MCFPRM4 Pall Microdisc Capsules with Pegasus Prime Virus Removal Filter Membrane 4/box
3MCFPRM12 Pall Microdisc Capsules with Pegasus Prime Virus Removal Filter Membrane 12/box
(4 x 3 lots)
 

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