Pall Microdisc Capsules with Pegasus™ Prime Virus Removal Filter Membrane product photo Primary L

Pall Microdisc Capsules with Pegasus™ Prime Virus Removal Filter Membrane

Small Virus Removal for Bioprocesses

Pall Pegasus Prime virus membrane provides robust virus retention to protect critical manufacturing bioprocesses, assure drug quality and safeguard health. These gamma irradiated filters combine high flow and robust capacity, to simplify your process and deliver sustainable economy at all scales.

The Microdisc capsules containing Pegasus Prime virus media are ideal for the confirmation and validation of performance at a small scale using minimal volumes of process fluid and virus spike preparations and deliver consistently high log reduction value (LRV) irrespective of the virus validation choices.

The predicted process flow, filter capacity or virus retention established during these studies scales to a range of products available to support your process at all scales and offer the highest degree of manufacturing control, flexibility and security.

Features and Benefits

 
Robust high LRV, independent of process fluid, process parameters or validation procedure Reliable performance and assured patient safety
  • Minimized risk of validation variation or failures ensures rapid process development
Robust capacity and high flow Small filtration footprints and short process times
  • Economic processes and easy integration into automated processes
Gamma irradiated > 25 kGy Virus clearance and process performance representative of larger manufacturing scale devices.
Full scale-up range with identical membrane at all scales Reliable scalability
  • Meaningful process prediction with minimal fluid volumes
Full pre-filter scale-up range with consistent pre-filter to virus filter area ratios Control scale-up risks
  • Faster, simplified scale-up
Easy to use Luer Lock connectivity for easy testing
 


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Capsules

List Price
$ 192.70
List Price
$ 433.58
Description

Small Virus Removal for Bioprocesses

Pall Pegasus Prime virus membrane provides robust virus retention to protect critical manufacturing bioprocesses, assure drug quality and safeguard health. These gamma irradiated filters combine high flow and robust capacity, to simplify your process and deliver sustainable economy at all scales.

The Microdisc capsules containing Pegasus Prime virus media are ideal for the confirmation and validation of performance at a small scale using minimal volumes of process fluid and virus spike preparations and deliver consistently high log reduction value (LRV) irrespective of the virus validation choices.

The predicted process flow, filter capacity or virus retention established during these studies scales to a range of products available to support your process at all scales and offer the highest degree of manufacturing control, flexibility and security.

Features and Benefits

 
Robust high LRV, independent of process fluid, process parameters or validation procedure Reliable performance and assured patient safety
  • Minimized risk of validation variation or failures ensures rapid process development
Robust capacity and high flow Small filtration footprints and short process times
  • Economic processes and easy integration into automated processes
Gamma irradiated > 25 kGy Virus clearance and process performance representative of larger manufacturing scale devices.
Full scale-up range with identical membrane at all scales Reliable scalability
  • Meaningful process prediction with minimal fluid volumes
Full pre-filter scale-up range with consistent pre-filter to virus filter area ratios Control scale-up risks
  • Faster, simplified scale-up
Easy to use Luer Lock connectivity for easy testing
 
Specifications
Materials of Construction
Filter Membrane: Polyethersulfone
Capsule Hardware: Polypropylene
Support Substrate : Polyester

Retention Ratings
Pore size : 20 nm nominal
Virus: > 4 log reduction value with mammalian parvoviruses

Effective Filter Area (EFA) (Nominal)
2.8 cm2 (0.43 in.2)

Operating Parameters
Maximum Temperature: 40 °C
Maximum Pressure: 3.1 bar (45 psi)*
Maximum Differential Pressure: 3.1 bar (45 psi)*
*up to 12 hours at 25 °C; up to 6 hours at 40 °C

Shelf Life
1 year

Liquid Flow v Differential Pressure (Typical)
1.4 – 2.6 mL/min at 2.1 bard, water at 20 °C

Dimensions (Nominal)
Length: 21 mm (0.8 in.)
Diameter: 29 mm (1.2 in.)

Connection Type
Female Luer-Lock inlet, male slip Luer outlet
Performance

Pegasus Prime delivers robust, high LRV independent of process parameters, process fluid and validation choices.


Figure 1
Robust, High Virus Retention

Tested using phage PP7
Tested using phage ?X174


Figure 2
Robust Virus Filter Sizing


The performance established during Microdisc filterability trials scales reliably to full scale devices as shown in Figure 3. Where intermediate scale trials to confirm the performance are required, Mini Kleenpak filterability tools are available and contain the same Pegasus Prime virus media in a low area, pleated filter configuration to minimize the volume of fluid required.


Figure 3
Robust Scaling

Polyclonal IgG at 50% flux decay; n≥9 from 3 different lots
Ordering Information

Ordering Information

 
Part Number Description Pkg
3MCFPRM4 Pall Microdisc Capsules with Pegasus Prime Virus Removal Filter Membrane 4/box
3MCFPRM12 Pall Microdisc Capsules with Pegasus Prime Virus Removal Filter Membrane 12/box
(4 x 3 lots)
 

OPTIONAL - Pegasus Protect Prefilter

 
4MCFPRT4 Pall Microdisc Capsules with Pegasus Protect Filter Membrane 4/box
 


Accessories

 
Part Number Description Pkg
C3EP1 Pall NovaSip™ empty capsule for use as a single-use pressure reservoir 1/pkg