Pall Kleenpak™ Capsules with Pegasus™ Protect Virus Prefilter Membrane
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Pegasus™ Protect membrane in Kleenpak™ capsule, 0.2 µm nominal pore size (adsorptive pre-filter), 286 cm² EFA, 1 in. Triclamp inlet connection and ½ in. Triclamp outlet connection, gamma irradiated
1/EA
1
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Datasheets
Download:Description
Tailored Tools for Scale-Up Confirmation
Pegasus Protect virus prefiltration combines with Pegasus Prime virus filtration to deliver the first gamma-sterilized pre-filter & virus filter combination. Together, these simplify process development, validation and operations while saving time and delivering improved process economy.
Process developers can quickly deliver a robust, scalable virus filtration process using a minimum of sample volume, and be confident of successful virus validation. This choice supports clinical manufacturing with a solution that is easy to use and versatile to work alone or with integrated and automated single-use systems.
Features and Benefits
| Removes filter plugging substances | Reduce plugging of Pegasus Prime virus filters
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| The scale-up range provides a consistent prefilter to virus filter area ratio at all scales | Consistent performance
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| Fully disposable capsule with ½ in. triclamp outlet | Easy to use
|
Specifications
Filter Membrane: Nylon
Support and Drainage: Polyester
Core and cage: Polypropylene
Capsule hardware: Polyester
Retention Ratings
Pore size : 0.2 μm nominal
Effective Filter Area (EFA) (Nominal)
286 cm2
Operating Parameters
Maximum Temperature: 40 °C
Maximum Pressure: 4.1 bar (60 psi)*
Maximum Differential Pressure: 4.1 bar (60 psi)*
Recommended Operating Conditions
35 mbard (0.5 psid) or 2 mL/min water at 20 °C*
*when used with Pegasus Prime Mini Kleenpak capsules at 2.1 bard (30 psid)
Steam Autoclaving
Cumulative autoclave time: 16 hours at 125°C*
4 hours at 140°C
* laboratory tests (1-hour cycles). Contact Pall for recommended procedures Warning; Kleenpak capsules must not be steam sterilized in-situ by passing steam through under pressure
Typical Hold-Up Volume (with air purge)
< 125 μL
Dimensions (Nominal)
Length: 11.7 cm (4.6 in.)
Diameter including valves: 9.4 cm (3.7 in.)
Connection Type
1 in. sanitary flange inlet
½ in. sanitary flange outlet
Performance
Impact of Pegasus Protect Prefiltration on Required Virus Flters Per Batch
Scalable Solutions
Prefiltration area and flowrate are critical variables that may affect the performance of Pegasus Protect prefiltration and Pegasus Prime virus removal filters when used in combination.
To control these variables Pegasus Protect prefiltration media is available in a range of formats, designed to maintain a consistent pre-filter to virus-filter ratio. This control ensures predictable and consistent performance at all scales from the initial Microdisc scale trials to clinical manufacturing.
| Area | Microdisc Capsules | Area | Kleenpak / Mini Kleenpak Capsules |
|
| Pegasus Protect Prefiltration | 3.9 cm2 |  |
286 cm2 |  |
| Pegasus Prime Virus Filter | 2.8 cm2 | 204 cm2 | ||
| Area ratio | 1.4 : 1 | 1.4 : 1 | ||
Type
Use
Related Documents
Regulatory/Quality Documentation
Ordering Information
| Part Number | Description | Pkg |
| KA1PRTP18FT | Pall Kleenpak Capsule with Pegasus Protect prefiltration media | 1/pkg |
| KA1PRT18FTR | Pall Kleenpak Capsule with Pegasus Protect prefiltration media - Gamma irradiated | 1/pkg |
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