SDR HyperD™ solvent-detergent removal chromatography sorbent is a unique sorbent designed to eliminate solvent and detergent from biological fluids.
It combines a silica-bead moiety filled with a three-dimensional cross-linked hydrophobic polymer. The particle size distribution (40-100 µm), the small pore size of the silica beads and the nature of the polymer have been optimized for a retention of solvents and detergents typically used in viral inactivation processes (i.e. Tri-n-Butyl Phosphate – TnBP – , Triton X-45 and Triton X-100).
The adsorption mechanism involves both the silica moiety and the hydrophobic polymer. The adsorption of Triton X-100 is proportional to the silica surface area, whereas the adsorption of TnBP is linked to binding to the organic polymer moiety. Large molecules are excluded.
Features and Benefits
- Efficient solvent and detergent removal from plasma fractions
- Easier to handle compared to conventional oil extraction or C18 chromatography methods
- Detergent removal from biological samples
- Rigid and mechanically stable for process scale