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AcroPak 1000 Capsules with Supor Membrane
AcroPak 1500 Capsules with Supor Membrane
AcroPak 500 Capsules with Supor Membrane
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Fast, Final Filtration and High Throughputs
for Liquid Volumes Up To 150 L
- Provides higher throughputs and faster flow rates than similarly-sized competitive devices
- Ideal for solutions requiring low protein binding
- Saves money by increasing throughput with available built-in prefilter
- 100% integrity testing assures sterile filtrate
- 0.1 μm Supor membrane version reduces mycoplasma levels in cell culture media
- Fusion-welded components eliminate the potential for release of extractables from sealing adhesives
- Sterilization by gamma irradiation eliminates potential contamination by EtO residuals
Video: Using an AcroPak Filter With a Peristaltic Pump
Specifications
Materials of Construction
- Filter Media: Supor [hydrophilic polyethersulfone (PES)] membrane
- Housing, Vent Plug, and Filter Support: Polypropylene
- Sealing Technology: Thermal bonding
- Filling Bell: Polycarbonate
Pore Size
- 0.1/0.1, 0.2/0.2, 0.8/0.2, and 0.8/0.45 μm
Effective Filtration Area
- 500 Series: 500 cm2
- 1000 Series: 1000 cm2
- 1500 Series: 1500 cm2
Dimensions
- Housing Diameter: 6.9 cm (2.7 in.)
- Overall Length (Without Filling Bell):
500 Series: 14.5 cm (5.7 in.)
1000 Series: 19.3 cm (7.6 in.)
1500 Series: 22.9 cm (9.0 in.)
Inlet/Outlet Connections
- 500 and 1000 Series: 6.4 - 12.7 mm (1/4 - 1/2 in.) stepped hose barb with filling bell on outlet
- 1500 Series: 12.7 mm (1/2 in.) straight hose barb, no filling bell on outlet
Typical Hold-Up Volume (with 10 psi air purge)
- 500 Series: 30 mL
- 1000 Series: 45 mL
Maximum Operating Temperature
- 60 °C (140 °F) at 2.1 bar (210 kPa, 30 psi)
Maximum Operating Pressure
- Continuous: 4.1 bar (410 kPa, 60 psi) at ambient temperature
Recommended Integrity Test Minimum Bubble Point – Water
- 0.2 μm: 3.5 bar (350 kPa, 51 psi)
- 0.45 μm: 1.7 bar (170 kPa, 24 psi)
- 60% IPA/40% H2O (v:v)
- 0.1 μm: 2.4 bar (240 kPa, 35 psi)
Typical Water Flow Rate
- Lpm at 0.1 bar (10 kPa) [Lpm/psi]:
Pore Size 500 Series 1000 Series 1500 Series 0.1/0.1 µm 0.2 (0.2) 0.4 (0.3) - 0.2/0.2 µm 0.6 (0.4) 1.1 (0.8) 1.6 (1.1) 0.8/0.2 µm 1.1 (0.8) 1.6 (1.1) 2.2 (1.5) 0.8/0.45 µm 1.3 (0.9) 2.5 (1.7) -
Bacterial Retention
- 0.1/0.1 μm Capsules: Lot samples retain a minimum of 107 cfu/cm2 of A. laidlawii challenge per modified ASTM F838, current revision
- 0.2 μm Capsules: Lot samples retain a minimum of 107 cfu/cm2 of B. diminuta per modified ASTM F838, current revision
Endotoxin Level
- < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test
Biological Safety
- Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>
Sterilization
- Sterilized by gamma irradiation
- If desired, autoclave once only prior to use at 121 - 123 °C (250 - 253 °F) for a maximum of 20 min.
Applications
- Large-volume media preparation
- Pilot-scale manufacturing
- Liquids requiring prefiltration, such as serum-containing media
- Sterile filtration of buffers
- Point-of-use filtration for laboratory water
- Reduce mycoplasma with the 0.1 µm pore size
Performance
Total Throughput Recorded for Devices with an EFA of Up to 1000 cm2

Throughput Determined using 3% TSB
Built-in Prefilter Enhances Total Throughput

Membrane Type: 47 mm Disc
Throughput Determined using 2.5 % TSB
Type
Filter Capsules
Product Summary
Fast, final filtration and high throughputs for liquid volumes up to 150L. Ideal for solutions requiring low protein binding. Provides higher throughputs and faster flow rates than similarly-sized competitive devices.
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