CytoSep* Membrane product photo Primary L

CytoSep* Membrane

Blended Fiber for Plasma Separation from Whole Blood

       

Composed of a patented blend of natural and synthetic fibers, CytoSep membrane is designed to separate plasma from whole blood. The media is intended for use in applications where less than 100 µ of whole blood would be applied to the surface of the material. The single layer nature of the media retains the red blood cells on the surface while the plasma, along with the platelets and leukocytes, move through the fibrous matrix. Plasma can be separated using the CytoSep membrane both vertically and laterally and can be optimized by the thickness of the material selected. Plasma generated by the CytoSep membranes will exhibit some hemolysis following filtration. The composite material does not contain binders or chemicals that may interfere with analyte measurements in diagnostic assays. Stronger than binder-free glass fiber, and available in a variety of thicknesses, CytoSep membrane can be easily manufactured in a variety of in vitro diagnostic test formats with minimal material scrap.



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Description

Blended Fiber for Plasma Separation from Whole Blood

       

Composed of a patented blend of natural and synthetic fibers, CytoSep membrane is designed to separate plasma from whole blood. The media is intended for use in applications where less than 100 µ of whole blood would be applied to the surface of the material. The single layer nature of the media retains the red blood cells on the surface while the plasma, along with the platelets and leukocytes, move through the fibrous matrix. Plasma can be separated using the CytoSep membrane both vertically and laterally and can be optimized by the thickness of the material selected. Plasma generated by the CytoSep membranes will exhibit some hemolysis following filtration. The composite material does not contain binders or chemicals that may interfere with analyte measurements in diagnostic assays. Stronger than binder-free glass fiber, and available in a variety of thicknesses, CytoSep membrane can be easily manufactured in a variety of in vitro diagnostic test formats with minimal material scrap.

Applications

Applications

  • Plasma separation
  • Diagnostic assays

Sealing

  • Mechanical
  • Adhesive
  • Lamination
  • Insert molding
Specifications

Typical Membrane Characteristics

Grade Base Material Typical Thickness (mils) Typical Thickness (µm) Basis Weight (g/m2)
1660 Proprietary blend of natural and synthetic fibers 9.6-15.7 243.8-398.8 62.2-84.4
1662 Proprietary blend of natural and synthetic fibers 22.0-26.0 558.8-660.4 137.1-147.6
1663 Proprietary blend of natural and synthetic fibers 34.0-48.0 863.6-1219.2 203.9-263.6

Typical Performance Characteristics

Grade Base Material Micron Rating Tensile Strength (lbs/in MD) Recommended Separation
1660 Proprietary blend of natural and synthetic fibers 2.8 µm 3.8 Lateral
1662 Proprietary blend of natural and synthetic fibers 3.5 µm 7.1 Lateral
1663 Proprietary blend of natural and synthetic fibers 3.4 µm --- Lateral and/or vertical

Performance
Grade Recommended Blood Volume ( µ) Total Absorption of Blood* Average Time for Plasma to Appear (sec) Average Distance of RBC Front (mm) Average Distance of Plasma Front (mm) Total Distance Traveled (mm) Area of Effect Containing RBC (%)
1660 20 630% 67.5 15.63 22.13 22.13 70.6
1662 30 475% 64.25 7.75 24.5 24.5 31.6
1663 40 455% 133.75 0 27.25 27.25 0

*(% blood wt/CytoSep wt +/- 50%)

Superior Plasma Separation Over Glass Fiber Materials

Picture depicts the images of test strips composed of blood separation media on top of an analytical membrane after completion of blood separation. In order to assess the media's ability to separate plasma from red blood cells, a 7.5 x 7.5 mm strip of media was placed on top of a piece of analytical membrane (30 mm x 7.5 mm) inside a Hemasep V housing. A known volume of blood (average hematocrit 44.1%) was then applied slowly in a drop-wise manner to the blood separation media. Volume added to the media was 60 µ for Glass Fiber A/D, 30 µ for CytoSep 1662, and 40 µ for CytoSep 1663. Notice that the red cell front is present on the analytical membrane after blood separation by glass fiber media while no red front is seen on the membrane after separation by either CytoSep media.

Type
Media, Membranes and Materials, Testing and Monitoring
Use
Separation, Diagnostics
Ordering Information

Custom roll, sheet, and disc sizes available upon request. Please contact your local sales representative for additional information.

Part Number Description Pkg
S70002 CytoSep Media Grade 1660, 8" x 10" sheet 1/pkg
S70004 CytoSep Media Grade 1662, 8" x 10" sheet 1/pkg
S70005 CytoSep Media Grade 1663, 8" x 10" sheet 1/pkg

Application
Diagnostics - Plasma Seperation, Diagnostics - Lateral Flow
Segment
Advanced Materials
Diagnostics