Cord Blood Cell Wash/Infusion Bag Set product photo Primary L

Cord Blood Cell Wash/Infusion Bag Set

For the thaw/washing and subsequent infusion of previously frozen cord blood stem cells as developed by the New York Blood Center.1, 2* This two-bag set is designed to achieve a slow asymptotic reduction in osmotic pressure of the cryoprotected white cells to the appropriate level for transfusion. Set reduces the DMSO content of the final stem cell transfusion to less than one gram. Each sterile set consists of two transfer bags joined by integral tubing, and three connector lines (two spikes and one luer).  Designed specifically for use with the freezing bag of the Transfer/Freezing Bag Set (PN 791-02) and the Freezing Bag (PN 791-05). Components include:
  • Two 250 mL capacity transfer bags. One 250 mL transfer bag is used for thawing the frozen unit with a Dextran/albumin solution. The second 250 mL transfer bag receives supernatant from the concentrated stem cells.1, 2*
  • Two multiple-use sampling sites.
  1. Rubinstein, P.; Dobrila, L.; Rosenfield, R.E.; Adamson, J.W.; Migliaccio, G.; Migliaccio, A.R.; Taylor, P.E.; Stevens, C.E. Processing and Cryopreservation of Placental/Umbilical Cord Blood for Unrelated Bone Marrow Reconstitution. Proc Natl Acad Sci USA. 1995, Oct 24;92(22):10119-22.
  2. Fraser, J.K.; Cairo, M.S.; Wagner, E.L.; McCurdy, P.R.; Baxter-Lowe, L.A.; Carter, S.L.; Kernan, N.A.; Lill, M.C.; Slone, V.; Wagner, J.E.; Wallas, C.H.; Kurtzberg, J. Cord Blood Transplantation Study (COBLT): Cord Blood Bank Standard Operating Procedures. Journal of Hematotherapy. 1998, 7(6):521-61.
*SOP available at the EMMES website: http://spitfire.emmes.com/study/cord/


* Required
Description
For the thaw/washing and subsequent infusion of previously frozen cord blood stem cells as developed by the New York Blood Center.1, 2* This two-bag set is designed to achieve a slow asymptotic reduction in osmotic pressure of the cryoprotected white cells to the appropriate level for transfusion. Set reduces the DMSO content of the final stem cell transfusion to less than one gram. Each sterile set consists of two transfer bags joined by integral tubing, and three connector lines (two spikes and one luer).  Designed specifically for use with the freezing bag of the Transfer/Freezing Bag Set (PN 791-02) and the Freezing Bag (PN 791-05). Components include:
  • Two 250 mL capacity transfer bags. One 250 mL transfer bag is used for thawing the frozen unit with a Dextran/albumin solution. The second 250 mL transfer bag receives supernatant from the concentrated stem cells.1, 2*
  • Two multiple-use sampling sites.
  1. Rubinstein, P.; Dobrila, L.; Rosenfield, R.E.; Adamson, J.W.; Migliaccio, G.; Migliaccio, A.R.; Taylor, P.E.; Stevens, C.E. Processing and Cryopreservation of Placental/Umbilical Cord Blood for Unrelated Bone Marrow Reconstitution. Proc Natl Acad Sci USA. 1995, Oct 24;92(22):10119-22.
  2. Fraser, J.K.; Cairo, M.S.; Wagner, E.L.; McCurdy, P.R.; Baxter-Lowe, L.A.; Carter, S.L.; Kernan, N.A.; Lill, M.C.; Slone, V.; Wagner, J.E.; Wallas, C.H.; Kurtzberg, J. Cord Blood Transplantation Study (COBLT): Cord Blood Bank Standard Operating Procedures. Journal of Hematotherapy. 1998, 7(6):521-61.
*SOP available at the EMMES website: http://spitfire.emmes.com/study/cord/
Applications

Application

For the thaw/washing and subsequent infusion of previously frozen cord blood stem cells as developed by the New York Blood Center.

 

Advanced Bag Designs Meet Rigorous Industry Standards

Cord blood stem cells have been effectively used in the treatment of more than 70 malignant and non-malignant diseases, including sickle cell, leukemia, non-Hodgkin's lymphoma, other forms of cancer, life-threatening anemias, and autoimmune diseases. As a key supplier to the cord blood banking industry, Pall provides a full range of bag sets that are used to prepare the cord blood stem cells for treatment. 

 

Pall's collection and processing sets are manufactured to cGMP using validated manufacturing processes that ensure safe, consistent and reliable product performance. Each bag is 100% inspected prior to release and is fully traceable by lot number. Pall's bag sets are uniquely designed to facilitate closed system processing of cord blood stem cells by the volume reduction method developed at the New York Blood Center.1 Volume reduction maximizes limited storage space while closed system processing minimizes sample loss and reduces the risk of contamination during handling. This method results in a high quality sample available for transplantation. SOP's referencing Pall bag sets are available at the EMMES website: https://web.emmes.com/study/cord/sop.htm1

 

Assessment of stem cell content and viability after long-term storage is a critical step prior to a successful transplantation. International standards recommend storing a cell sample attached to a unit of cord blood for quality control testing. Pall's freezing bag includes sufficient tubing for the preparation of segments, enabling a sample aliquot to be cryopreserved with the final product. Using a tube segment for quality control testing prior to transplantation reduces the risk of contamination during the thawing process and provides critical information needed to predict treatment success.

 

Cord Blood Cell Wash/Infusion Bag Set

 

For disease treatments or patient populations that require a higher cell dose to be transplanted, Pall's advanced freezing bag design divides the sample into two compartments, facilitating transfusion of 80% of the stem cells while retaining 20% of the stem cells for ex vivo cell expansion. Scientific advances in our ability to amplify stem cells will greatly expand the applications for hematopoietic stem cells from cord blood. 

 

1. Rubinstein, P.; Dobrila, L.; Rosenfield, R.E.; Adamson, J.W.; Migliaccio, G.; Migliaccio, A.R.;Taylor, P.E.; Stevens, C.E. Processing and Cryopreservation of Placental/Umbilical Cord Blood for Unrelated Bone Marrow Reconstitution. Proc Natl Acad Sci USA. 1995, Oct 24;92(22):10119-22.
Specifications
 
Product No. 791-03, 791-03U
Description

Cell Wash/Infusion Bag Set

Fill Volume Range Up to 250 mL
Port Configuration (2) in-line spikes; in-line luer; (2) multi-use sampling ports
Materials of Construction Bags: Polyvinyl chloride (PVC) with tri (2-ethylhexyl) trimelliate (TEHTM) plasticizer; Tubing: Ethylene vinyl acetate
Bag Size(s) 17.53 cm length x 11.43 cm width (6.91 in. length x 4.5 in. width)
Sterilization Gamma
Packaging Individually packaged in a plastic pouch; 24/box
Shelf Life 3 years
Traceability Lot number
Regulatory Status FDA 510(k) cleared : 791-02, 791-03, 791-05
CE marked: 791-02U, 791-03U, 791-05U
791-02U : Canadian medical device license # 101446
791-03U : Canadian medical device license # 91523
791-05U : Canadian medical device license # 101437
Compatible with Other Bags 791-02; 791-05; 791-02U; 791-05U
 
Ordering Information
 
Product CodeProduct Code (Europe, Canada)DescriptionPackaging
       
791-03 791-03U Cell Wash/Infusion Bag Set 24 units/case
 


To Order, Contact:

Pall Medical

Tel: 877.367.7255
Fax: 888.556.7337
uscustomerservice@pall.com

Pall Europe Ltd

Europa House, Havant Street
Portsmouth, PO1 3PD England
Tel: +44 (0)23 9230 3452
Fax: +44 (0)23 9230 3324
Biosvc@Pall.com

Pall Canada

Pall Canada Ltd.
3450 Ridgeway Drive, Unit 6
Mississauga, ON L5L 0A2
Canada

Access our complete list of Pall offices worldwide.

Segment
Cord Blood