1.2 µm nylon membrane
- Smooth housing design
- Sterile, non-pyrogenic fluid pathway
- Phthalate-free tubing extension
- Removes particles and microorganisms
- Retains oversized lipid droplets
- Eliminates air (independent of filter position)
- Easy to prime and use
- Increases patient comfort
Filter Media1.2 µm nylon membrane
Priming Volume2.3 mL
SterilitySterile and non-pyrogenic fluid pathway
Maximum Recommended Flow Rate300 mL/hour
Maximum Working PressureApproximately 22 psi (1.5 bar)
- Particulate contamination arises from infusion systems and components due to manipulations5, and interactions between components6. Particles can be deposited in the microvasculature of the lungs and other organs, resulting in serious clinical consequences7,8. Gross precipitation in admixtures, which may not be visible when lipid is present, has proven fatal in cases6.
- Oversized lipid droplets arise in admixtures due to instability. Large numbers may lodge in the lung microvasculature and produce an embolic syndrome1.
- Microbial contamination can inadvertently arise in infusion systems due to manipulations. Parenteral nutrition is an acknowledged risk for fungemia with Candida spp. being among the most common organisms involved8. Malassezia furfur is also emerging as an increasingly important pathogen in neonates3, having demonstrated the ability to grow in lipid-containing preparations3,9.
- Driscoll, D.F., Bacon, M.N., & Bistrian, B.R. Effects of in-line filtration on lipid particle size distribution in total nutrient admixtures. JPEN J Parenter Enteral Nutr. 1996; 20:296-301.
- Barnett, M.I. Filtration of lipid-containing total parenteral nutrition (TPN) admixture. Clin Nutr. 1995; 14:49.
- Robinson, R. & Ball, P. Presented at the New Zealand Hospital Pharmacists Association Meeting. October, 1996, Auckland, NZ.
- Coppa, G.F., Gouge, T.H., & Hofstetter, S.R. Air embolism: a lethal but preventable complication of subclavian vein catheterization. JPEN J Parenteral Enteral Nutr. 1981; 5:166-8.
- Foroni, L.A., Rochat, M.H., Trouiller, P., & Calop, J.Y. Particle contamination in a ternary nutritional admixture. J Parenter Sci Technol. 1993; 47:311-4.
- United States Food & Drug Administration Safety Alert: Hazards of precipitation associated with parenteral nutrition. April 18, 1994.
- Walpot, H., Franke, R.P., Burchard,W.G., Agternkamp, C., Muller, F.G., & Mittermayer, C., et al. Particulate contamination of infusion solutions and drug additives within the scope of long-term intensive therapy. Anaesthesist. 1989; 38:544-8.
- Lehr, H.A., Brunner, J., Rangoonwala, R., & Kirkpatrick, C.J. Particulate matter contamination of intravenous antibiotics aggravates loss of functional capillary density in postischemic striated muscle. Am J Respir Crit Care Med. 2002; 165:514-20.
- Vazquez, J.A., Sanchez, V., Dmuchowski, C., Dembry, L.M., Sobel, J.D., & Zervos, M.J. Nosocomial acquisition of Candida albicans: an epidemiologic study. J Infect Dis. 1993; 168:195-201.
|Total Nutrient Admixture Filters|
|TNA1||Total Nutrient Admixture Filter||40/case|