Depth Filters

 

Depth filters are ideally suited for demanding prefiltration, cell harvesting, and post virus inactivation clarification processes in biopharmaceutical and biotech applications. Biotech depth filters remove cell debris and contaminants, ensuring better protection to downstream purification processes such as chromatography and sterile filtration.

Depth Filtration

Supracap 50 Capsules
Supracap 50 Capsules

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Biotech

Supracap™ 50 depth filter capsule with single-layer media grade K200P (3-6 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade K200P (3-6 µm retention rating) and luer-lock connections

Product ID: SC050P200
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
3-6 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade K250P (4-9 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade K250P (4-9 µm retention rating) and luer-lock connections

Product ID: SC050P250
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
4-9 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade BIO 10 (0.2-0.4 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade BIO 10 (0.2-0.4 µm retention rating) and luer-lock connections

Product ID: SC050B010
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
0.2-0.4 µm
Membrane Material
Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade SUPRA 80P (1-3 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade SUPRA 80P (1-3 µm retention rating) and luer-lock connections

Product ID: SC050P080
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
1-3 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade BIO 20 (0.4-1 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade BIO 20 (0.4-1 µm retention rating) and luer-lock connections

Product ID: SC050B020
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
0.4-1.0 µm
Membrane Material
Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with dual-layer media grade PDD2 (0.2-0.8 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with dual-layer media grade PDD2 (0.2-0.8 µm retention rating) and luer-lock connections

Product ID: SC050PDD2
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
0.2-0.8 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade SUPRA EK1P (0.2-0.5 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade SUPRA EK1P (0.2-0.5 µm retention rating) and luer-lock connections

Product ID: SC050PEK1
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
0.2-0.5 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade T1500P (11-30 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade T1500P (11-30 µm retention rating) and luer-lock connections

Product ID: SC050P1500
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
11-30 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with dual-layer media grade PDK5 (1.5-20 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with dual-layer media grade PDK5 (1.5-20 µm retention rating) and luer-lock connections

Product ID: SC050PDK5
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
1.5-20 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade K100P (1-3 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade K100P (1-3 µm retention rating) and luer-lock connections

Product ID: SC050P100
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
1-3 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with single-layer media grade K700P (6-15 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with single-layer media grade K700P (6-15 µm retention rating) and luer-lock connections

Product ID: SC050P700
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
6-15 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
Supracap™ 50 depth filter capsule with dual-layer media grade PDE4 (0.4-3 µm retention rating) and luer-lock connections product photo

Supracap™ 50 depth filter capsule with dual-layer media grade PDE4 (0.4-3 µm retention rating) and luer-lock connections

Product ID: SC050PDE4
Unit of Measure
1/EA
Min Order Qty
1
Retention Rating
0.4-3 µm
Membrane Material
Regenerated Cellulose
Maximum Batch Volume
3 L
Effective Filtration Area (Metric)
22 cm²
See All Attributes
27 Items

 

 

Description

 

Pall offers a wide range of media product families of biotech depth filters to accommodate clarification applications such as monoclonal antibodies, vaccines, gene therapy, human blood plasma, and API. Pall also offers wide range of device formats to accommodate process development and single use manufacturing.

 

 

Depth Filter Comparisons

 

Specification Supracap 50 Supracap 100 Supradisc Stax
Media Grade Available in all depth filter media grades
Media Material Cellulose
Capsule Material Polypropylene
Autoclave Sterilizable 125 ºC at 30 minutes 125 ºC at 60 minutes 60 minutes at 125 ºC 2 autoclave cycles: 60 minutes at 125 ºC
Steam Sterilizable N/A N/A

125 °C (257 °F) for 30 minutes

at 0.3 bard (4.3 psid) maximum

 N/A
Maximum Differential Pressure 1.5 bar (22 psi) 2.4 bar (35 psi) 2.4 bard (35 psid) 2.4 bar (35 psi) at 25 °C – forward direction
Maximum Operating Pressure 3 bar (44 psi) @ 40 ºC 3 bar (44 psi) @ 40 ºC 80 °C (176 °F)

3.5 bar (50 psi) at 25 °C

1.0 bar (14.3 psi) at 60 °C
Effective Filter Area 22 cm2 0.025 m2 – 0.3 m2 0.3 m2 – 5 m2 0.5 m2 – 2m2
Suitable Process Scale <1-3 L 3 – 100+ L 50 – 20,000+ L 50 – 20,000+ L

 

 

Device format by process scale

 

 

Device format by process scale

 

Media grades comparison

 

 

Seitz Bio-series
  • Single layer media made of highly purified, natural/modified cellulose fibers
  • No inorganic additives such as diatomaceous earth (DE), perlite, or glass fiber
  • Low release of extractables
  • Low protein adsorption
Seitz P-Series
  • Single layer media specially developed for biotech/pharmaceutical industry, high purity medium
  • Contains inorganic additives such as diatomaceous earth (DE), perlite, or glass fiber
  • No recycled materials
  • Low virus retention
Seitz AKS-Series
  • Embedded with activated carbon
  • Suitable for decolorization and removal of other impurities
Seitz HP-Series
  • Double layer of P-Series depth filter sheets
  • Suitable for low viability/high solid containing applications

 

 

Media grade retention ratings

 

 

Media grade retention ratings

 

Shop by media grade

 

Applications

 

 

Considerations when Selecting Media
Particle Distribution Size
  • Cell size
  • Total and viable cell density
  • Cell viability
  • Lysis process
Cell Culture
  • Adherent or suspension
  • Cell line
  • Bioreactor or shake flask

 

 

Below are depth filter recommendations for common applications. Media grade can vary based on process conditions so multiple options are provided where appropriate.  Please consult a Pall expert before confirming your selection.

 

 

Applications Recommended Depth Filter

mAbs and Recombinant Protein Clarification

(Recombinant proteins produced in mammalian or insect cell lines)

Media: PDP8+PDE2

Platform: Stax Max
Gene Therapy AAV Clarification

Adherent Cell Culture

Media: V100P, PDK11, Bio10

 

Suspension Cell Culture

Media: PDK11, PDP8+Bio10
Gene Therapy LV Clarification

Adherent Cell Culture

Media: V100P

 

Suspension Cell Culture

Media: V100P, PDK11, PDP8+V100P
Microbial Fermentation Clarification

Lysed

Media: PDE2, PDH4

 

Not Lysed

Product: Stax CF Cake Filtration
Yeast Clarification Product: Stax CF Cake Filtration
Decolorization Media: AKS-Series

 

 

Depth filter media can be scaled up from process development to commercial. Proof of concept can be performed at process development by a Pall expert scale upon request.

 

 

Process Scale Recommended Device Format
Process Development Supracap 50 and Supracap 100
Pilot Scale Supracap 100 and Stax
Commercial Product Scale Stax and Supradisc

 

 

Need more help choosing the right filter? 

 

Our Scientific and Laboratory Services (SLS) team have been helping our customers optimize their processes for more than 50 years. Together with our wide range of filter membranes, we can find the right filtration solution or help to optimize your sterile filtration process. 

 

Our Process Development Services (PDS) team can reduce your development time. Our proven methods and integrated bioprocess solutions can help drive down costs and risks.

 

Request a consultation with one of our depth filtration specialists to discuss your process and offer free support to help you get it right.

 

 

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