AcroPak™ 1000 Capsules with Supor Membrane - 0.8/0.2 µm, gamma-irradiated (1/pkg)

Materials of Construction

• Filter Media: Supor [hydrophilic polyethersulfone (PES)] membrane
• Housing, Vent Plug, and Filter Support: Polypropylene
• Sealing Technology: Thermal bonding
• Filling Bell: Polycarbonate

Pore Size

• 0.1/0.1, 0.2/0.2, 0.8/0.2, and 0.8/0.45 μm

Effective Filtration Area

• 500 Series: 500 cm²
• 1000 Series: 1000 cm²
• 1500 Series: 1500 cm²

Dimensions

• Housing Diameter: 6.9 cm (2.7 in.)
• Overall Length (Without Filling Bell):
     500 Series: 14.5 cm (5.7 in.)
     1000 Series: 19.3 cm (7.6 in.)
     1500 Series: 22.9 cm (9.0 in.)

Inlet/Outlet Connections

• 500 and 1000 Series: 6.4 - 12.7 mm (1/4 - 1/2 in.) stepped hose barb with filling bell on outlet
• 1500 Series: 12.7 mm (1/2 in.) straight hose barb, no filling bell on outlet

Typical Hold-Up Volume (with 10 psi air purge)

• 500 Series: 30 mL
• 1000 Series: 45 mL

Maximum Operating Temperature

• 60 °C (140 °F) at 2.1 bar (210 kPa, 30 psi)

Maximum Operating Pressure

• Continuous: 4.1 bar (410 kPa, 60 psi) at ambient temperature

Recommended Integrity Test Minimum Bubble Point – Water

• 0.2 μm: 3.5 bar (350 kPa, 51 psi)
• 0.45 μm: 1.7 bar (170 kPa, 24 psi)
• 60% IPA/40% H2O (v:v)
• 0.1 μm: 2.4 bar (240 kPa, 35 psi)

Typical Water Flow Rate

• Lpm at 0.1 bar (10 kPa) [Lpm/psi]:

  Pore Size	500 Sereis	1000 Sereis	1500 Series
  0.1/0.1 µm	0.2 (0.2)	0.4 (0.3)	-
  0.2/0.2 µm	0.6 (0.4)	1.1 (0.8)	1.6 (1.1)
  0.8/0.2 µm	1.1 (0.8)	1.6 (1.1)	2.2 (1.5)
  0.8/0.45 µm	1.3 (0.9)	2.5 (1.7)	-

Bacterial Retention

• 0.1/0.1 μm Capsules: Lot samples retain a minimum of 10⁷ cfu/cm² of A. laidlawii challenge per modified ASTM F838, current revision
• 0.2 μm Capsules: Lot samples retain a minimum of 10⁷ cfu/cm² of B. diminuta per modified ASTM F838, current revision

Endotoxin Level

• < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test

Biological Safety

• Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>

Sterilization

• Sterilized by gamma irradiation
• If desired, autoclave once only prior to use at 121 - 123 °C (250 - 253 °F) for a maximum of 20 min.

• Large-volume media preparation
• Pilot-scale manufacturing
• Liquids requiring prefiltration, such as serum-containing media
• Sterile filtration of buffers
• Point-of-use filtration for laboratory water
• Reduce mycoplasma with the 0.1 µm pore size

Total Throughput Recorded for Devices with an EFA of Up to 1000 cm²

Throughput Determined using 3% TSB

Built-in Prefilter Enhances Total Throughput

Membrane Type: 47 mm Disc
Throughput Determined using 2.5 % TSB

• Acrodisc® Syringe Filters with Supor Membrane
• AcroCap™ Positive Pressure Devices
• VacuCap® Vacuum Filtration Devices
• AcroPak™ 200 Capsules with Supor® Membranes
• Stainless Steel Pressure Vessels