Pall Kleenpak™ Capsules with Pegasus™ Protect Virus Prefilter Membrane product photo Primary L

Pall Kleenpak™ Capsules with Pegasus™ Protect Virus Prefilter Membrane

Tailored Tools for Scale-Up Confirmation

Pall Pegasus Protect virus prefiltration membrane is tailored to provide protection to Pegasus Prime virus filters and to deliver the highest level of robust filter performance in more challenging process fluids. The combination of Pegasus Protect and Pegasus Prime filters increases throughput and leads to a reduction in processing costs by a reduction in virus filter sizing and processing times.

During preclinical process development it may be desirable to confirm the predicted throughput and flowrate using larger, pleated format devices. The Kleenpak filterability tool containing Pegasus Protect prefiltration media is designed to maintain a constant area ratio between prefiltration and virus filtration at this scale and is optimized for use with Mini Kleenpak capsules containing Pegasus Prime virus removal membrane.

Features and Benefits

 
Removes filter plugging substances Reduce plugging of Pegasus Prime virus filters
  • Smaller virus filter sizing
  • Minimized cost of goods
  • Shorter processing timesIncreased robustness to natural process fluid variation
The scale-up range provides a consistent prefilter to virus filter area ratio at all scales Consistent performance
  • Controlling scaling risks
  • Faster, simple scale-up and viral validation
Fully disposable capsule with ½ in. triclamp outlet Easy to use
  • Direct connection to Mini Kleenpak filterability tool containing Pegasus Prime virus removal media
 


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Capsules

List Price
$ 215.00
Description

Tailored Tools for Scale-Up Confirmation

Pall Pegasus Protect virus prefiltration membrane is tailored to provide protection to Pegasus Prime virus filters and to deliver the highest level of robust filter performance in more challenging process fluids. The combination of Pegasus Protect and Pegasus Prime filters increases throughput and leads to a reduction in processing costs by a reduction in virus filter sizing and processing times.

During preclinical process development it may be desirable to confirm the predicted throughput and flowrate using larger, pleated format devices. The Kleenpak filterability tool containing Pegasus Protect prefiltration media is designed to maintain a constant area ratio between prefiltration and virus filtration at this scale and is optimized for use with Mini Kleenpak capsules containing Pegasus Prime virus removal membrane.

Features and Benefits

 
Removes filter plugging substances Reduce plugging of Pegasus Prime virus filters
  • Smaller virus filter sizing
  • Minimized cost of goods
  • Shorter processing timesIncreased robustness to natural process fluid variation
The scale-up range provides a consistent prefilter to virus filter area ratio at all scales Consistent performance
  • Controlling scaling risks
  • Faster, simple scale-up and viral validation
Fully disposable capsule with ½ in. triclamp outlet Easy to use
  • Direct connection to Mini Kleenpak filterability tool containing Pegasus Prime virus removal media
 
Specifications
Materials of Construction
Filter Membrane: Nylon
Support and Drainage: Polyester
Core and cage: Polypropylene
Capsule hardware: Polyester

Retention Ratings
Pore size : 0.2 μm nominal

Effective Filter Area (EFA) (Nominal)
286 cm2

Operating Parameters
Maximum Temperature: 40 °C
Maximum Pressure: 4.1 bar (60 psi)*
Maximum Differential Pressure: 4.1 bar (60 psi)*

Recommended Operating Conditions
35 mbard (0.5 psid) or 2 mL/min water at 20 °C*
*when used with Pegasus Prime Mini Kleenpak capsules at 2.1 bard (30 psid)

Steam Autoclaving
Cumulative autoclave time: 16 hours at 125°C*
4 hours at 140°C
* laboratory tests (1-hour cycles). Contact Pall for recommended procedures Warning; Kleenpak capsules must not be steam sterilized in-situ by passing steam through under pressure

Typical Hold-Up Volume (with air purge)
< 125 μL

Dimensions (Nominal)
Length: 11.7 cm (4.6 in.)
Diameter including valves: 9.4 cm (3.7 in.)

Connection Type
1 in. sanitary flange inlet
½ in. sanitary flange outlet
Performance
Figure 1
Impact of Pegasus Protect Prefiltration on Required Virus Flters Per Batch

Scalable Solutions

Prefiltration area and flowrate are critical variables that may affect the performance of Pegasus Protect prefiltration and Pegasus Prime virus removal filters when used in combination.

To control these variables Pegasus Protect prefiltration media is available in a range of formats, designed to maintain a consistent pre-filter to virus-filter ratio. This control ensures predictable and consistent performance at all scales from the initial Microdisc scale trials to clinical manufacturing.

 
  Area Microdisc Capsules Area Kleenpak / Mini
Kleenpak Capsules
Pegasus Protect Prefiltration 3.9 cm2 286 cm2
Pegasus Prime Virus Filter 2.8 cm2 204 cm2
Area ratio 1.4 : 1 1.4 : 1
 
Ordering Information
 
Part Number Description Pkg
KA1PRTP18FT Pall Kleenpak Capsule with Pegasus Protect prefiltration media 1/pkg
 

Pegasus Prime Virus Removal Filters

 
KA02PRM8FT Pall Mini Kleenpak Filterability Tool with Pegasus Prime Virus Removal Filter Membrane. Supplied sterile. 3/pkg
 

Scale-down Devices

 
4MCFPRT4 Pall Microdisc Capsules with Pegasus Protect prefiltration membrane 1/pkg
4MCFPRT12 Pall Microdisc Capsules with Pegasus Protect prefiltration membrane 12/box
(4 x 3 lots)
 

Clinical Scale Filters

 
AB2PRT7PH4 Pall 508 mm (20 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 1.4 m2 1/pkg
N*7PRTP1 Pall 508 mm (20 in.) Kleenpak Nova filter capsules with Pegasus Protect prefiltration membrane. Nominal area 1.4 m2 1/pkg
AB3UPRM7PH4 Pall 762 mm (30 in.) filter cartridges with Pegasus Protect prefiltration membrane. Nominal area 2.1 m2 1/pkg
N*8PRTP1 Pall 762 mm (30 in.) Kleenpak Nova filter capsules with Pegasus Protect prefiltration membrane. Nominal area 2.1 m2 1/pkg
 
* [P] – In-line flow / [T] - T-style flow