Depth filters are ideally suited for demanding prefiltration, cell harvesting, and post virus inactivation clarification processes in biopharmaceutical and biotech applications. Biotech depth filters remove cell debris and contaminants, ensuring better protection to downstream purification processes such as chromatography and sterile filtration.
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Pall offers a wide range of media product families of biotech depth filters to accommodate clarification applications such as monoclonal antibodies, vaccines, gene therapy, human blood plasma, and API. Pall also offers wide range of device formats to accommodate process development and single use manufacturing.
Depth Filter Comparisons
| Specification | Supracap 50 | Supracap 100 | Supradisc | Stax |
|---|---|---|---|---|
| Media Grade | Available in all depth filter media grades | |||
| Media Material | Cellulose | |||
| Capsule Material | Polypropylene | |||
| Autoclave Sterilizable | 125 ºC at 30 minutes | 125 ºC at 60 minutes | 60 minutes at 125 ºC | 2 autoclave cycles: 60 minutes at 125 ºC |
| Steam Sterilizable | N/A | N/A | 125 °C (257 °F) for 30 minutes at 0.3 bard (4.3 psid) maximum |
N/A |
| Maximum Differential Pressure | 1.5 bar (22 psi) | 2.4 bar (35 psi) | 2.4 bard (35 psid) | 2.4 bar (35 psi) at 25 °C – forward direction |
| Maximum Operating Pressure | 3 bar (44 psi) @ 40 ºC | 3 bar (44 psi) @ 40 ºC | 80 °C (176 °F) | 3.5 bar (50 psi) at 25 °C 1.0 bar (14.3 psi) at 60 °C |
| Effective Filter Area | 22 cm2 | 0.025 m2 – 0.3 m2 | 0.3 m2 – 5 m2 | 0.5 m2 – 2m2 |
| Suitable Process Scale | <1-3 L | 3 – 100+ L | 50 – 20,000+ L | 50 – 20,000+ L |
Device format by process scale
Media grades comparison
| Seitz Bio-series |
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| Seitz P-Series |
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| Seitz AKS-Series |
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| Seitz HP-Series |
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Media grade retention ratings
| Considerations when Selecting Media | |
|---|---|
| Particle Distribution Size |
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| Cell Culture |
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Below are depth filter recommendations for common applications. Media grade can vary based on process conditions so multiple options are provided where appropriate. Please consult a Pall expert before confirming your selection.
| Applications | Recommended Depth Filter |
|---|---|
mAbs and Recombinant Protein Clarification (Recombinant proteins produced in mammalian or insect cell lines) |
Media: PDP8+PDE2 Platform: Stax Max |
| Gene Therapy AAV Clarification | Adherent Cell Culture Media: V100P, PDK11, Bio10
Suspension Cell Culture Media: PDK11, PDP8+Bio10 |
| Gene Therapy LV Clarification | Adherent Cell Culture Media: V100P
Suspension Cell Culture Media: V100P, PDK11, PDP8+V100P |
| Microbial Fermentation Clarification | Lysed Media: PDE2, PDH4
Not Lysed Product: Stax CF Cake Filtration |
| Yeast Clarification | Product: Stax CF Cake Filtration |
| Decolorization | Media: AKS-Series |
Depth filter media can be scaled up from process development to commercial. Proof of concept can be performed at process development by a Pall expert scale upon request.
| Process Scale | Recommended Device Format |
|---|---|
| Process Development | Supracap 50 and Supracap 100 |
| Pilot Scale | Supracap 100 and Stax |
| Commercial Product Scale | Stax and Supradisc |
Need more help choosing the right filter?
Our Scientific and Laboratory Services (SLS) team have been helping our customers optimize their processes for more than 50 years. Together with our wide range of filter membranes, we can find the right filtration solution or help to optimize your sterile filtration process.
Our Process Development Services (PDS) team can reduce your development time. Our proven methods and integrated bioprocess solutions can help drive down costs and risks.
Request a consultation with one of our depth filtration specialists to discuss your process and offer free support to help you get it right.
