Depth Filters

 

Depth filters are ideally suited for demanding prefiltration, cell harvesting, and post virus inactivation clarification processes in biopharmaceutical and biotech applications. Biotech depth filters remove cell debris and contaminants, ensuring better protection to downstream purification processes such as chromatography and sterile filtration.

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Industrial Manufacturing

Red1000 Glass Fiber 12 micron (Beta 1000) Nitrile 36in 91.44cm

Product ID: HC2296FKS36H
Unit of Measure
1/EA
Min Order Qty
6
Anti-Static
No
Beta Rating
BETA 1000
Element Series
HC2296
Family
Red1000
Filter Media
Glass Fiber
Filter Removal Rating (μm)
12 µm
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Ultipor III Glass Fiber 5 micron (Beta 1000) Nitrile 8in 20.32cm length

Product ID: HC9601FDP8H#28
Unit of Measure
1/EA
Min Order Qty
1
Anti-Static
No
Beta Rating
BETA 1000
Element Series
HC9601
Family
Ultipor III
Filter Media
Glass Fiber
Filter Removal Rating (μm)
5 µm
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DFT Classic®, Filter Cartridges, Removal Rating 1 μm, Length 30 Inches, 304 stainless steel product photo

DFT Classic®, Filter Cartridges, Removal Rating 1 μm, Length 30 Inches, 304 stainless steel

Product ID: C001AW30A
Unit of Measure
1/EA
Min Order Qty
1
DFT Classic®, Filter Cartridges, Removal Rating 5 μm, Length 9.75 Inches, 304 stainless steel, Bulk packaging product photo

DFT Classic®, Filter Cartridges, Removal Rating 5 μm, Length 9.75 Inches, 304 stainless steel, Bulk packaging

Product ID: C005A975A
Unit of Measure
30/EA
Min Order Qty
30
Packaging
Bulk
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DFT Classic®, Filter Cartridges, Removal Rating 10 μm, Length 20 Inches, Polypropylene

Product ID: C010AW20U
Unit of Measure
10/EA
Min Order Qty
10
Removal Rating
10 µm
Cartridge Length (Imperial)
20 in
Cartridge Length (Metric)
508 mm
Cartridge Length (Metric)
50.8 cm
Cartridge Outer Diameter (OD) (Imperial)
2.5 in
Cartridge Outer Diameter (OD) (Metric)
6.4 cm
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DFT Classic®, Filter Cartridges, Removal Rating 20 μm, Length 20 Inches, Polypropylene

Product ID: C020AW20U
Unit of Measure
10/EA
Min Order Qty
10
Removal Rating
20 µm
Cartridge Length (Imperial)
20 in
Cartridge Length (Metric)
508 mm
Cartridge Length (Metric)
50.8 cm
Cartridge Outer Diameter (OD) (Imperial)
2.5 in
Cartridge Outer Diameter (OD) (Metric)
6.4 cm
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DFT Classic®, Filter Cartridges, Removal Rating 30 μm, Length 10 Inches, 304 stainless steel

Product ID: C030A10A
Unit of Measure
30/EA
Min Order Qty
30
Removal Rating
30 µm
Cartridge Length (Imperial)
10 in
Cartridge Length (Metric)
254 mm
Cartridge Length (Metric)
25.4 cm
Cartridge Outer Diameter (OD) (Imperial)
2.5 in
Cartridge Outer Diameter (OD) (Metric)
6.4 cm
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DFT Classic®, Filter Cartridges, Removal Rating 100 μm, Length 10 Inches, 304 stainless steel product photo

DFT Classic®, Filter Cartridges, Removal Rating 100 μm, Length 10 Inches, 304 stainless steel

Product ID: C100A10A
Unit of Measure
30/EA
Min Order Qty
30
Packaging
Bulk
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C10P-AHP

Product ID: C10PAHP
Unit of Measure
20/EA
Min Order Qty
20

C10P-PHP

Product ID: C10PPHP
Unit of Measure
20/EA
Min Order Qty
20

SepraSol L/G Coalescer, 30in length, 2.75in diameter, 99.999% at 0.3µm aerosol rating, 99.99% >0.3µm solids removal rating

Product ID: CC3LGA7H13
Unit of Measure
1/EA
Min Order Qty
1
Maximum Operating Temperature (F)
180 °F
Maximum Operating Temperature (C)
82 °C
Change out pressure drop (bar)
0.83 bar
Change out pressure drop (psid)
12 psid
Maximum differential pressure rating (bar)
2.75 bar
Maximum differential pressure rating (psid)
40 psid
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Claris® Filter Cartridges, Polypropylene, Length 20 inches

Product ID: CLR0520843
Unit of Measure
24/EA
Min Order Qty
24
Membrane Material
Polypropylene
Cartridge Length (Imperial)
20 in
Cartridge Length (Metric)
508 mm
Cartridge Length (Metric)
50.8 cm
Change Out Differential Pressure
2.4 bard
Cartridge Outer Diameter (OD) (Imperial)
2.5 in
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Description

 

Pall offers a wide range of media product families of biotech depth filters to accommodate clarification applications such as monoclonal antibodies, vaccines, gene therapy, human blood plasma, and API. Pall also offers wide range of device formats to accommodate process development and single use manufacturing.

 

 

Depth Filter Comparisons

 

Specification Supracap 50 Supracap 100 Supradisc Stax
Media Grade Available in all depth filter media grades
Media Material Cellulose
Capsule Material Polypropylene
Autoclave Sterilizable 125 ºC at 30 minutes 125 ºC at 60 minutes 60 minutes at 125 ºC 2 autoclave cycles: 60 minutes at 125 ºC
Steam Sterilizable N/A N/A

125 °C (257 °F) for 30 minutes

at 0.3 bard (4.3 psid) maximum

N/A
Maximum Differential Pressure 1.5 bar (22 psi) 2.4 bar (35 psi) 2.4 bard (35 psid) 2.4 bar (35 psi) at 25 °C – forward direction
Maximum Operating Pressure 3 bar (44 psi) @ 40 ºC 3 bar (44 psi) @ 40 ºC 80 °C (176 °F)

3.5 bar (50 psi) at 25 °C

1.0 bar (14.3 psi) at 60 °C

Effective Filter Area 22 cm2 0.025 m2 – 0.3 m2 0.3 m2 – 5 m2 0.5 m2 – 2m2
Suitable Process Scale <1-3 L 3 – 100+ L 50 – 20,000+ L 50 – 20,000+ L

 

 

Device format by process scale

 

 

 

Media grades comparison

 

 

Seitz Bio-series
  • Single layer media made of highly purified, natural/modified cellulose fibers
  • No inorganic additives such as diatomaceous earth (DE), perlite, or glass fiber
  • Low release of extractables
  • Low protein adsorption
Seitz P-Series
  • Single layer media specially developed for biotech/pharmaceutical industry, high purity medium
  • Contains inorganic additives such as diatomaceous earth (DE), perlite, or glass fiber
  • No recycled materials
  • Low virus retention
Seitz AKS-Series
  • Embedded with activated carbon
  • Suitable for decolorization and removal of other impurities
Seitz HP-Series
  • Double layer of P-Series depth filter sheets
  • Suitable for low viability/high solid containing applications

 

 

Media grade retention ratings

 

 

 

Shop by media grade

 

Applications

 

 

Considerations when Selecting Media
Particle Distribution Size
  • Cell size
  • Total and viable cell density
  • Cell viability
  • Lysis process
Cell Culture
  • Adherent or suspension
  • Cell line
  • Bioreactor or shake flask

 

 

Below are depth filter recommendations for common applications. Media grade can vary based on process conditions so multiple options are provided where appropriate.  Please consult a Pall expert before confirming your selection.

 

 

Applications Recommended Depth Filter

mAbs and Recombinant Protein Clarification

(Recombinant proteins produced in mammalian or insect cell lines)

Media: PDP8+PDE2

Platform: Stax Max

Gene Therapy AAV Clarification

Adherent Cell Culture

Media: V100P, PDK11, Bio10

 

Suspension Cell Culture

Media: PDK11, PDP8+Bio10

Gene Therapy LV Clarification

Adherent Cell Culture

Media: V100P

 

Suspension Cell Culture

Media: V100P, PDK11, PDP8+V100P

Microbial Fermentation Clarification

Lysed

Media: PDE2, PDH4

 

Not Lysed

Product: Stax CF Cake Filtration

Yeast Clarification Product: Stax CF Cake Filtration
Decolorization Media: AKS-Series

 

 

Depth filter media can be scaled up from process development to commercial. Proof of concept can be performed at process development by a Pall expert scale upon request.

 

 

Process Scale Recommended Device Format
Process Development Supracap 50 and Supracap 100
Pilot Scale Supracap 100 and Stax
Commercial Product Scale Stax and Supradisc

 

 

Need more help choosing the right filter? 

 

Our Scientific and Laboratory Services (SLS) team have been helping our customers optimize their processes for more than 50 years. Together with our wide range of filter membranes, we can find the right filtration solution or help to optimize your sterile filtration process. 

 

Our Process Development Services (PDS) team can reduce your development time. Our proven methods and integrated bioprocess solutions can help drive down costs and risks.

 

Request a consultation with one of our depth filtration specialists to discuss your process and offer free support to help you get it right.