Suspended-Screen Ultrafiltration Cassettes with Omega™ Membrane :  Centramate™ and Centrasette™ II Cassettes product photo Primary L

Suspended-Screen Ultrafiltration Cassettes with Omega™ Membrane: 
Centramate™ and Centrasette™ II Cassettes

  • Optimized for solutions that are highly viscous and highly concentrated
  • And for solutions containing cells, cellular debris, and particles

Suspended-screen Omega polyethersulfone (PES)  membrane cassettes provide excellent membrane permeability and consistent performance in high viscosity and high concentration ultrafiltration applications. Tangential flow filtration (TFF) cassettes with Omega PES membrane scale up easily and are suited to a broad range of cleaning options

Pall’s tangential flow filtration (TFF) suspended-screen cassettes with Omega membrane are intended for ultrafiltration (UF) applications. The cassette contains an Omega low protein-binding modified polyethersulfone membrane.

They are available in two formats – Centramate and Centrasette II cassettes – and in a range of molecular weight cut-offs (MWCO) from 1 kDa to 300 kDa to meet most application requirements.

The suspended-screen channel configuration is well suited for particles/cells/cell debris in solution and for high viscosity solutions.

Proven Omega Membrane

Pall's Omega polyethersulfone membranes offer high flux throughout the range of selectivities. They have been specifically modified to minimize protein binding to the surface and interstitial structure of the membrane. This polymeric membrane is stable against biological and physical degradation due to the unique chemical properties of PES.

Omega membranes are cast on a highly porous, non-woven polyolefin support. They have an anisotropic structure, a thin skin-like top layer with a highly porous underlying support. The structure of the skin determines the porosity and permeability characteristics of the membrane and can typically be cleaned quicker and easier than membranes with a uniform, sub-micron depth structure. This membrane is compatible with acids, bases and a variety of other cleaning agents. Omega membranes are available in a wide range of nominal molecular weight cutoffs (NMWC).



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Description
  • Optimized for solutions that are highly viscous and highly concentrated
  • And for solutions containing cells, cellular debris, and particles

Suspended-screen Omega polyethersulfone (PES)  membrane cassettes provide excellent membrane permeability and consistent performance in high viscosity and high concentration ultrafiltration applications. Tangential flow filtration (TFF) cassettes with Omega PES membrane scale up easily and are suited to a broad range of cleaning options

Pall’s tangential flow filtration (TFF) suspended-screen cassettes with Omega membrane are intended for ultrafiltration (UF) applications. The cassette contains an Omega low protein-binding modified polyethersulfone membrane.

They are available in two formats – Centramate and Centrasette II cassettes – and in a range of molecular weight cut-offs (MWCO) from 1 kDa to 300 kDa to meet most application requirements.

The suspended-screen channel configuration is well suited for particles/cells/cell debris in solution and for high viscosity solutions.

Proven Omega Membrane

Pall's Omega polyethersulfone membranes offer high flux throughout the range of selectivities. They have been specifically modified to minimize protein binding to the surface and interstitial structure of the membrane. This polymeric membrane is stable against biological and physical degradation due to the unique chemical properties of PES.

Omega membranes are cast on a highly porous, non-woven polyolefin support. They have an anisotropic structure, a thin skin-like top layer with a highly porous underlying support. The structure of the skin determines the porosity and permeability characteristics of the membrane and can typically be cleaned quicker and easier than membranes with a uniform, sub-micron depth structure. This membrane is compatible with acids, bases and a variety of other cleaning agents. Omega membranes are available in a wide range of nominal molecular weight cutoffs (NMWC).

Applications

Centramate Suspended-Screen Ultrafiltration Cassettes with Omega Membrane

Centramate suspended-screen cassettes with Omega membrane are perfect for laboratory scale and development applications in TFF. The cassettes are supplied with the same construction materials as used in the Centrasette membrane cassettes.

Centramate suspended-screen cassettes with Omega membrane are perfect for laboratory scale and development applications in TFF. The cassettes are supplied with the same construction materials as used in the Centrasette membrane cassettes.

Applications developed on a Centramate suspended-screen cassettes with Omega membrane can be easily scaled up by adding cassettes to a Centramate holder or by switching to the Centrasette cassette format with identical path length and channel format.

Please refer to Table 3 for a list of formats available for Centramate cassettes.


Centrasette II Suspended-Screen Ultrafiltration Cassettes with Omega Membrane

Centrasette II suspended-screen cassettes with Omega membrane have been widely used for years in various process applications including concentration and diafiltration by the biopharmaceutical industry. They are available with membrane areas of 0.5 m2 and 2.5 m2 (5.4 ft2 and 27 ft2). Larger cassette areas simplify installation in large TFF systems, reducing the number of gaskets required and minimizing risk of leakage.

Pall continues to improve membrane cassettes to meet the more rigid requirements of today’s applications.

The Centrasette II suspended-screen cassettes with Omega membrane use the same components as in the original Centrasette cassette. Therefore, revalidation may not be necessary. Feed ports in the Centrasette II cassette have been enlarged to twice the size of the Centrasette cassette and membrane area has been increased by about 10%. The larger fluid port design will enhance the membrane’s performance by:

  • Improving fluid flow distribution between and through cassettes
  • Allowing more efficient cleaning
  • Reducing the pressure profile across the feed/retentate channels
Centrasette (left) and Centrasette II (right) cassettes feed port comparison

The Centrasette II suspended-screen cassettes with Omega membrane are available with 2 different membrane area options to meet small scale and larger process volume requirements (see Table 3).

Specifications
Table 1 - Materials of construction
 
Membrane Omega low protein-binding modified polyethersulfone
Encapsulant Polyurethane
Screens Polyester
Spacers Polyolefin/PES
 

Cassettes pass current USP Biological Safety Tests for Class VI Plastics at 70 °C.

Storage Agents

Pall’s suspended-screen ultrafiltration cassettes with Omega membrane are shipped wet, in liquid containing a humectant and bactericidal storage solution. This solution consists of 15–20% glycerin, and 0.05–0.1% sodium azide.

The storage solution must be removed and the cassette flushed well with water prior to use to prevent product contamination.

Traceability

Each suspended-screen ultrafiltration cassette with Omega membrane has a unique serial number for full traceability. Each cassette is supplied with:

  • Certificate of quality
  • Membrane cassette care and use procedures
  • Material safety data sheet (MSDS) for cassette preservative
  • Two platinum-cured silicon gaskets

Complementary Products

Cassette holders are available, please contact Pall for details.

Ordering Information
How to order suspended-screen ultrafiltration cassettes with Omega membrane:
  1. Membrane type is OS (Omega TFF low protein-binding modified polyethersulfone).
  2. Choose an MWCO from Table 2 (e.g., 010 = 10 kDa).
  3. Choose a format code from Table 3 (e.g., C11 or F07).

Typical example of part number: : OS 010 F07

Table 2 – Available MWCOs for Pall’s suspended-screen ultrafiltration cassettes with Omega membrane
 
Code MWCO (kDa)
001 1
003 3
005 5
010 10
030 30
050 50
100 100
300 300
 

Table 3 – Formats for suspended-screen ultrafiltration cassettes with Omega membrane
 
Cassette Format Nominal Area Code
Centramate 0.01 m2 (0.1 ft2) C11P1
0.02 m2 (0.2 ft2) C11P2
0.1 m2 (1.0 ft2) C11
Centrasette II 0.5 m2 (5.4 ft2) F07
2.5 m2 (27 ft2) F27
 
Segment
Tangential Flow Filtration